Nā huahana

ʻO ka 1-Methyl-4-pyrazole boronic acid pinacol ester he mea hoʻohui kemika e pāʻani koʻikoʻi i ke kahua o ka kemika organik a me ka ʻike lāʻau.Loaʻa iā ia kahi moiety waikawa boronic, kahi mea e lilo ai ia i mea nui hale kūkulu no ka synthesizing ʻano mole mole.Hoʻohana pinepine ʻia ma ke ʻano he precursor a i ʻole waena i ka synthesis o nā pūhui pharmaceutical.ʻIke ʻia nā waikawa Boronic no ko lākou hiki ke hana i nā paʻa paʻa me kekahi mau enzymes, ʻoi aku ka proteases.Hāʻawi kēia waiwai iā lākou i nā mea hana kūpono no ka hoʻomohala ʻana i nā inhibitor enzyme hiki ke koho i nā maʻi kikoʻī.Ma ka hoʻokomo ʻana i ka moiety pyrazole i loko o ka waika boronic, hōʻike ka pūhui i hoʻohui ʻia i hoʻonui ʻia i ka pilina paʻa a me ke koho ʻana i ka enzyme target.Hoʻolilo kēia i ka 1-Methyl-4-pyrazole boronic acid pinacol ester i hale kūkulu waiwai no ka ʻimi ʻana i ka lāʻau lapaʻau e kuhikuhi ana i nā maʻi protease e like me ka maʻi maʻi, ʻāʻī, a me nā maʻi viral. Hiki i ka pinacol ester ke hana i nā ʻano hoʻohālikelike like ʻole, e like me ka pane ʻana o Suzuki-Miyaura cross-coupling a me ka pane Heck.Hāʻawi kēia mau hopena i ka hoʻokumu ʻana i nā mea paʻa kalapona-carbon, e hoʻomaʻamaʻa i ka synthesis o nā hale paʻakikī.Hoʻohui ka hui pyrazole i nā ʻano like ʻole a me nā hana i nā pūhui synthesized, e hana ana i ka 1-Methyl-4-pyrazole boronic acid pinacol ester he mea hoʻohui nui i ka synthesis organik. ka hoʻomohala ʻana i nā mea hana boron.ʻO ka hui waika boronic he mau waiwai kūʻokoʻa e hiki ai iā ia ke komo i nā kaʻina hana hoʻohui ponoʻī, e alakaʻi ana i ka hoʻokumu ʻana o nā hale supramolecular.Ua ʻimi ʻia kēia mākaukau ma ke kahua o ka ʻepekema waiwai e hana i nā mea hana, e like me nā gels, nā kiʻiʻoniʻoni, a me nā nanoparticles, hiki ke loaʻa nā noi i ka uila, catalysis, a me ka hāʻawi ʻana i ka lāʻau. ʻO ka pinacol ester kahi hui nui me ka nui o nā noi.ʻO kāna hana waika boronic e hiki ai i ka synthesis o nā molekala organik paʻakikī, e hoʻolilo iā ia i hale kūkulu pono i ka ʻike lāʻau a me ka synthesis organik.Hoʻohui ʻia, hiki i kāna mau waiwai kūʻokoʻa ke hoʻokumu i nā mea supramolecular me nā mea hiki ke hoʻohana ʻia i nā ʻano ʻano like ʻole.ʻO ka holoʻokoʻa, ʻo kona ʻano multifaceted e hana i ka 1-Methyl-4-pyrazole boronic acid pinacol ester i mea waiwai nui no ka poʻe noiʻi ma nā ʻano ʻepekema like ʻole.