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ʻO 2-(3-Formyl-4-hydroxy-phenyl) -4-methyl-thiazole-5-carboxylic acid ethyl ester he mea hoʻohui kemika e paʻa ana i ka ʻōlelo hoʻohiki ma ke kahua o nā lāʻau lapaʻau ma muli o kona ʻano kū hoʻokahi a me nā hana olaola.Hiki ke hoʻohana ʻia kēia pūhui i nā noi lāʻau lapaʻau like ʻole a me nā kaʻina hana ʻike lāʻau. no ka hana ʻana i nā lāʻau lapaʻau hou.Aia i loko o kona hale nā ​​pūʻulu hana e hiki ke hoʻololi a hoʻololi ʻia, e ʻae ana i nā mea lapaʻau lapaʻau e hoʻolauna i nā substituent like ʻole a hana i nā molekala like ʻole me nā waiwai pharmacological i hoʻonui ʻia.Ma ka hoʻololi pono ʻana i kēia pūhui, hiki i nā mea noiʻi ke hana i kahi waihona o nā derivatives no nā haʻawina pili i ka structure-activity (SAR), e loiloi ana i ka hopena o nā hoʻololi like ʻole i ka mana o ka lāʻau, koho, a me nā waiwai pharmacokinetic. , hiki ke ʻimi ʻia no nā noi lapaʻau kūpono.ʻO ka loaʻa ʻana o kahi apo thiazole a me kahi pūʻulu formyl me kahi moiety phenolic e hōʻike ana e hiki ke loaʻa iā ia nā waiwai antioxidant a me nā anti-inflammatory.ʻImi pinepine ʻia kēia mau waiwai i ka hoʻomohala ʻana i ka lāʻau lapaʻau, no ka mea hiki iā lākou ke kōkua i ka pale ʻana a i ʻole ka mālama ʻana i nā maʻi like ʻole e pili ana i ke kaumaha oxidative a me nā kaʻina inflammatory, e like me nā maʻi cardiovascular a i ʻole nā ​​kūlana neurodegenerative. ʻO ka 2-(3-Formyl-4-hydroxy- Hiki ke hoʻohana ʻia ka phenyl) -4-methyl-thiazole-5-carboxylic acid ethyl ester no ke aʻo ʻana i ka hoʻopaʻa ʻana i ka enzyme a me nā pilina enzyme-substrate.Pāʻani koʻikoʻi nā enzyme i nā kaʻina hana olaola like ʻole a pili pinepine i nā maʻi.Ma ka hoʻolālā ʻana i nā analogs o kēia pūhui a me ka noiʻi ʻana i kā lākou pilina me nā enzymes kikoʻī, hiki i nā mea noiʻi ke loaʻa nā ʻike i ka hana enzymatic a hiki ke ʻike i nā pahuhopu lāʻau hou, ʻoi aku hoʻi no nā kūlana e pili ana i ka enzymatic dysfunction. .ʻO kāna ʻano hana kūikawā kūpono ia no ka hoʻopaʻa ʻana i nā noiʻi a me ka hoʻohālike molekala, kahi e hiki ai i nā mea noiʻi ke wānana i ke ʻano hoʻopaʻa ʻana o ka pūhui me nā protein i hoʻopaʻa ʻia a hoʻopaʻa pono i kāna mau pilina e hoʻonui ai i ka pono. I ka hopena, 2-(3-Formyl-4-hydroxy-phenyl) -4-methyl-thiazole-5-carboxylic acid ethyl ester hōʻike i ka pono kūpono i ka lāʻau kemika a me ka ʻike lāʻau.Hiki iā ia ke lilo i wahi hoʻomaka waiwai no ka synthesis o nā pūhui hou me nā waiwai pharmacological i hoʻonui ʻia.Hoʻohui ʻia, ʻo kāna mau hana biological intrinsic a me ka launa pū ʻana me nā enzyme e lilo ia i moho hoihoi no ka ʻimi hou ʻana i nā noi therapeutic.ʻO ka hoʻomau ʻana i ka noiʻi a me ka noiʻi e wehe i ka mana piha o kēia pūhui i ka hoʻomohala ʻana i nā lāʻau lapaʻau hou a me ka hoʻomaopopo ʻana i nā kaʻina hana olaola.