Nā huahana

ʻO 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone, ka mea maʻamau i kapa ʻia ʻo TMS-D-glucose, kahi pūhui versatile e loaʻa ai nā noi i nā ʻano ʻepekema like ʻole, me ka synthesis organik, kemika carbohydrate, a me ke kemika analytical. He mea waiwai nui ka TMS-D-glucose i ka synthesis organik no ka mea he hui pale ia no ka hui hana hydroxyl (OH) i loko o nā kaʻa.Ma ka hoʻokomo ʻana i nā pūʻulu trimethylsilyl (TMS) i nā pūʻulu hydroxyl o ka glucose, lilo ka pūhui i ʻoi aku ka paʻa a me ka liʻiliʻi o ka reactive, e ʻae ana i ka hoʻololi koho ʻana i nā pūʻulu hydroxyl kikoʻī a waiho ʻia nā poʻe ʻē aʻe i ka hopena i ka wā o ka hoʻololi kemika.Hoʻohana nui ʻia kēia hoʻolālā pale-deprotection i ka kemika carbohydrate e hoʻokō i ka regioselectivity a me ka stereochemistry i ka synthesis o nā carbohydrates paʻakikī, glycoconjugates, a me nā huahana kūlohelohe. o ka waiʻaleʻa.Ma ka hoʻololi ʻana i nā ʻakika i loko o kā lākou trimethylsilyl derivatives, hoʻomaikaʻi ko lākou volatility a me ke kūpaʻa wela, e kūpono iā lākou no ka nānā ʻana e ke gas chromatography (GC) a me ka mass spectrometry (MS).Hoʻonui kēia ʻenehana derivatization i ka ʻike ʻike, hoʻomaikaʻi i ka hoʻokaʻawale ʻana, a hiki ke ʻike i nā ʻano carbohydrates i loko o nā hui paʻakikī, e like me nā laʻana olaola a i ʻole nā ​​huahana meaʻai.ʻO kona ʻano hana kūʻokoʻa a me kona kūpaʻa e lilo ia i mea hoʻomaka waiwai no ka hoʻomākaukau ʻana i nā mea hoʻohui i loaʻa i ka carbohydrate.Hiki i nā mea noiʻi ke hoʻololi i ka trimethylsilyl moiety a i ʻole ke hoʻololi i ka moiety glucose e hana i nā pūhui me nā waiwai kikoʻī, e like me nā fluorescent probes, enzyme inhibitors, a i ʻole nā ​​moho lāʻau.Hiki ke hoʻohana ʻia kēia mau derivatives i nā haʻawina olaola a me nā biomedical like ʻole, me ke kiʻi kiʻi, ka hoʻomohala ʻana i ka lāʻau lapaʻau, a i ʻole ka hoʻomaopopo ʻana i ka launa pū ʻana o ka carbohydrate-protein. hoʻomalu.Pono nā mea noiʻi e hōʻoia i ka ea kūpono a hoʻohana i nā lako pale pilikino kūpono i ka wā e hana pū ai me kēia pūhui e pale ai i nā pōʻino olakino.Hoʻohui, e like me nā mea hoʻohui kemika, ka maʻemaʻe, a me ka maikaʻi o TMS-D-glucose he mea koʻikoʻi ia e loaʻa ai nā hopena hilinaʻi a hiki ke hana hou ʻia.ʻO kona hiki ke pale pono i nā pūʻulu hydroxyl i loko o nā kaʻa, kona hoʻohana ʻana i ka nānā ʻana i ka carbohydrate, a me kāna pono i ka synthesis o nā reagents kūikawā e lilo ia i mea pono i nā ʻano ʻepekema.Ma ka hoʻohana ʻana i ka TMS-D-glucose, hiki i nā mea noiʻi ke holomua i kā lākou aʻo ʻana i ka kemika carbohydrate, glycoscience, a me nā pā e pili ana, e hāʻawi ana i ka hoʻomohala ʻana i nā pūhui hou, diagnostics, a me nā mea lapaʻau.