Nā huahana

ʻO ka pūhui (2S,3R,4R,5S,6R) -2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol he mole kalapona paʻakikī me nā hoʻohana koʻikoʻi koʻikoʻi ma ka ʻoihana kemika a me ka lāʻau lapaʻau.ʻO ka loaʻa ʻana o nā pūʻulu chloro, ethoxybenzyl, a me hydroxymethyl ka manawa e ʻimi ai i ka pilina o ka pūhui me nā pahuhopu olaola a loiloi i kona hiki ke lilo i mea lapaʻau.Hōʻike ke ʻano o ka pūhui e loaʻa iā ia ka hana lāʻau lapaʻau a hōʻike paha i ka hiki ke ʻike i ka lāʻau.Hiki i nā mea noiʻi ke hana i nā haʻawina like ʻole, me nā hoʻokolohua in vitro a me in vivo, e loiloi i ka hana biological o ka pūhui, ka hana o ka hana, a me ka hiki ke hoʻōla.Hiki i ke stereochemistry kūikawā o ka pūhui, me ka hui pū ʻana o nā hoʻonohonoho S a me R, hiki ke kōkua i kāna hana olaola, e lilo ia i mea mole hoihoi no ka hoʻokolokolo hou ʻana.Hiki i nā mea noiʻi ke hoʻohana i kēia pūhui i mea hoʻomaka no ka synthesis o nā molekala paʻakikī a i ʻole nā ​​​​huahana huahana kūlohelohe.Ma ka hana ʻana i nā hoʻololi koho i nā pūʻulu hana o ka mole, hiki i ka poʻe kemika ke loaʻa i nā pūhui me nā waiwai i makemake ʻia, e like me ka hoʻomaikaʻi ʻana i ka lāʻau lapaʻau, hoʻomaikaʻi i ka solubility, a i ʻole ka hōʻemi ʻana i ka ʻona.ʻO ka loaʻa ʻana o ka hui hydroxymethyl e wehe i nā mea hiki ke hoʻololi hou aku, e like me ka hoʻololi ʻana iā ia i loko o nā pūʻulu hana like ʻole, e ʻae ai i ka hoʻomākaukau ʻana i kahi waihona waihona like ʻole o nā pūhui no nā noi like ʻole. ʻAʻole pono e mālama ʻia.ʻO ka loaʻa ʻana o nā kikowaena chiral he nui i ka mole e hiki ai ke hoʻomākaukau i nā pūhui enantiomerically maʻemaʻe, he mea koʻikoʻi i ka ʻoihana lāʻau.Hiki i nā mea kemika ke ʻimi i ka pono o ka pūhui i ke kūkulu ʻana i nā molekole chiral paʻakikī, hiki ke alakaʻi i ka loaʻa ʻana o nā lāʻau lapaʻau hou a i ʻole ka hoʻomohala ʻana i nā ʻano hana synthetic hou.Pono nā mea noiʻi e makaʻala a hahai i nā kaʻina palekana kūpono ma ke kaʻina holoʻokoʻa, mai ka synthesis a hiki i ke ʻano a me ka lawelawe ʻana. phenyl] -6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol e hōʻike ana i ka mana koʻikoʻi i loko o ka lāʻau lapaʻau kemika, synthetic organic chemistry, a me asymmetric synthesis.ʻO kona hoʻolālā kūʻokoʻa a me ka stereochemistry e wehe i nā ala no ka hoʻomaopopo ʻana i kāna hana olaola, ka hoʻolālā ʻana i nā mea lapaʻau hou, a me ka hoʻomohala ʻana i nā hoʻolālā synthetic no ka hana ʻana i nā molekala organik paʻakikī.Hiki ke hoʻomau i ka ʻimi ʻana i nā waiwai a me nā noi o kēia pūhui i ka holomua o ka hoʻomohala ʻana i ka lāʻau lapaʻau, synthesis kemika, a me ka hoʻomaopopo ʻana i nā ʻōnaehana olaola.