Nā huahana

(3R,4R) -1-(tert-Butoxycarbonyl)-4-methylpyrrolidine-3-carboxylic acid, i ʻike ʻia ʻo Boc-4-methylproline, he mea hoʻohui kemika i hoʻohana nui ʻia ma ke kahua o ka synthesis organik, ʻoi loa i ka hana ʻana o peptides a me peptidomimetics no nā noi like ʻole. ʻO kekahi o nā hoʻohana nui o Boc-4-methylproline ma ke ʻano he hui pale no ka hui amino o nā waikawa amino i ka wā o ka peptide synthesis.ʻO nā hui pale he mau hoʻololi pōkole e pale ana i nā pūʻulu hana kūikawā o nā molekala e pale i nā hopena makemake ʻole i ka wā o ka hana synthetic.I ka peptide synthesis, hoʻohana ʻia ʻo Boc-4-methylproline ma ke ʻano he pūʻulu pale no ka hui amine, e ʻae ana i ka hoʻopili koho ʻana o nā waikawa amino ʻē aʻe e hana i ke kaʻina peptide makemake. ka hui ʻana o nā pūhui like ʻole me nā hana olaola.Ma ke ʻano he hui chiral, loaʻa iā ia kahi stereocenter, e hāʻawi ana i ʻelua enantiomers: (3R,4R) -Boc-4-methylproline a me (3S,4S) -Boc-4-methylproline.Hiki i kēlā me kēia enantiomer ke hōʻike i nā waiwai lāʻau lapaʻau like ʻole a me ka launa pū ʻana me nā pahuhopu olaola.Ma ka hoʻohana ʻana iā Boc-4-methylproline ma ke ʻano he mea hoʻomaka, hiki i nā chemists ke komo i kahi ʻano o nā pūhui chiral no ka ʻike ʻana a me ka hoʻomohala ʻana i ka lāʻau.Ua noiʻi ʻia kēia mau pūhui no ko lākou hiki ke lilo i mea lapaʻau e kūʻē i nā pathogens like ʻole, me ka bacteria, nā maʻi maʻi, a me nā maʻi kanesa.Ma ka hoʻololi ʻana i ke ʻano o Boc-4-methylproline a me ka loiloi ʻana i kāna mau derivatives, hiki i nā mea noiʻi ke ʻimi i ko lākou hiki ke like me nā pūhui alakaʻi a i ʻole nā ​​molekole scaffold no ka hoʻolālā lāʻau. i ka hana ʻana i nā peptidomimetics.ʻO nā Peptidomimetics nā pūhui e hoʻohālike i ke ʻano a me ka hana o nā peptides akā loaʻa i ka paʻa paʻa a me nā waiwai pharmacokinetic.Hiki i ka Boc-4-methylproline ke lilo i hale kūkulu i ka hoʻolālā a me ka synthesis o peptidomimetics, e ʻae ai i ka hoʻomohala ʻana i nā therapeutics hou me ka bioavailability maikaʻi a me ka kikoʻī kikoʻī. ʻO 4-methylpyrrolidine-3-carboxylic acid, a i ʻole Boc-4-methylproline, he mea hoʻohana nui i hoʻohana nui ʻia i ka synthesis organik.ʻO kāna kuleana ma ke ʻano he pūʻulu pale i ka peptide synthesis, a me kāna mau waiwai chiral, e lilo ia i mea waiwai nui no ka hana ʻana i nā peptides, peptidomimetics, a me nā pūhui chiral.Ke noiʻi ʻia nei nā derivatives o Boc-4-methylproline no kā lākou mau hana olaola hiki ke loaʻa, ʻo ia hoʻi nā waiwai antimicrobial, antiviral, a me anticancer.Hoʻomau ka noiʻi a me ka hana hou i ka hoʻohana ʻana iā Boc-4-methylproline i ka hoʻolālā lāʻau lapaʻau e kōkua i ka hoʻomohala ʻana i nā mea lapaʻau hou a hoʻomaikaʻi i ko mākou ʻike i nā kaʻina hana koʻikoʻi paʻakikī.