Nā huahana

ʻO Acetoxy Empagliflozin, i kapa ʻia ʻo empagliflozin acetate, he ʻano hoʻololi o ka lāʻau antidiabetic empagliflozin.Aia ʻo Empagliflozin i kahi papa o nā lāʻau i kapa ʻia ʻo sodium-glucose co-transporter 2 (SGLT2) inhibitors, i hoʻohana mua ʻia no ka mālama ʻana i ka maʻi diabetes type 2. Hana ʻo Empagliflozin ma ke kāohi ʻana i ka SGLT2, kahi protein e kuleana no ka hoʻihoʻi ʻana i ka glucose i loko o nā puʻupaʻa.Ma ke kāohi ʻana i kēia pūmua, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one he hui kemika paʻakikī me kahi inoa kemika lōʻihi.Hāʻule ia ma lalo o ka papa o triMethylsilyloxy pyranones, i hoʻohana nui ʻia i nā noiʻi ʻepekema a me nā ʻenehana. (triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ma ke ʻano he hui pale i ka synthesis organik.ʻO nā pūʻulu pale he mau pūʻulu hana manawaleʻa i hoʻohana ʻia no ka pale ʻana i nā wahi reactive kikoʻī ma kahi mole i ka wā o ka hopena kemika.I ka hihia o (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, hana nā pūʻulu triMethylsilyloxy i mau ʻāpana pale. .I ka wā o ka pane ʻana, pale kēia mau pūʻulu i kekahi mau pūʻulu hana mai ka loaʻa ʻana o nā hopena i makemake ʻole ʻia, e ʻae ana i nā hopena i makemake ʻia e holo mālie.Ma hope o ka pau ʻana o ka hopena, hiki ke wehe maʻalahi nā hui triMethylsilyloxy, e hōʻike ana i nā hui hana mua. ʻO Methyl)tetrahydro-2H-pyran-2-one aia i ka synthesis o nā mea hoʻohui.Hiki ke hoʻohana ʻia ma ke ʻano he pā hale e kūkulu i nā hale paʻakikī.ʻO kāna mau waiwai kemika kūʻokoʻa a me ka hana hou ʻana e lilo ia i mea hana waiwai i ka hoʻomohala ʻana i nā mea kemika hou.Hiki i nā kemika ke hoʻohana (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one e hoʻolauna i nā hui hana kūikawā scaffolds e aʻo i nā hana olaola o nā pūhui a i ʻole e hoʻomohala i nā lāʻau hou.Hiki i kona noho ʻana ma ke ʻano he hui hana i loko o kahi mole ke hāʻawi i kekahi mau waiwai i makemake ʻia i nā mea.No ka laʻana, hiki ke hoʻonui i ka solubility i nā mea hoʻoheheʻe kūikawā a i ʻole ka hoʻomaikaʻi ʻana i nā waiwai hana kiʻiʻoniʻoni, e hoʻohana pono ai i nā uhi a i ʻole nā ​​mea hoʻopili.(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy)-6-(( triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one he hui kūikawā nui me ka hoʻohana nui ʻana i nā ʻano ʻepekema a me nā ʻoihana.ʻO kona hiki ke hana ma ke ʻano he pūʻulu pale a lawelawe ma ke ʻano he hale kūkulu i ka synthetic chemistry, a me kāna mau noi kūpono i ka ʻepekema waiwai, e lilo ia i mea waiwai i ka hoʻomohala ʻana i nā molekala a me nā mea hou.Eia nō naʻe, ʻokoʻa paha kāna mau noi a me kāna hoʻohana ʻana, ma muli o nā koi kikoʻī a me nā pahuhopu o kahi papahana ʻepekema a ʻoihana paha.