Nā huahana

(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, ʻike ʻia hoʻi ʻo TBDMS-protected tetrahydro-2H-pyran -2-hoʻokahi, he mea hoʻohui i hoʻohana mau ʻia i ka synthesis organik a ma ke ʻano he hui pale ma ke kahua o ke kemika. o nā molekalakala paʻakikī.Loaʻa i ka pūhui nā pūnaewele reactive he nui i hiki ke hoʻololi i nā hoʻololi pūʻulu hana.ʻO ka pūʻulu pale TBDMS (tert-butyldimethylsilyl) i loaʻa i loko o ka mole e hāʻawi i ka paʻa a hiki ke hoʻololi koho i nā pūʻulu hana kikoʻī.Hana kēia versatility i ka TBDMS-protected tetrahydro-2H-pyran-2-one i mea waiwai nui i ka synthesis o nā huahana kūlohelohe, pharmaceuticals, a me nā kemika maikaʻi ʻē aʻe. kuleana ma ke ʻano he pūʻulu pale no nā ʻona a me nā amine i ka synthesis organik.Hiki ke hoʻohui ʻia ka pūʻulu TBDMS i nā pūʻulu hydroxyl a i ʻole nā ​​amino, me ka hoʻomaʻamaʻa pono iā lākou i ka wā o nā ʻano hana.Mālama kēia pale i nā ʻaoʻao ʻaoʻao i makemake ʻole ʻia a hōʻoia i ka hoʻololi ʻana i makemake ʻia ma nā pūnaewele i makemake ʻia.Ke pau nā hopena i makemake ʻia, hiki ke wehe maʻalahi ka hui TBDMS, e hōʻike ana i ka hui hydroxyl a i ʻole ka hui amino me ka ʻole o ka hoʻopili ʻana i nā hana ʻē aʻe i loko o ka mole. carbohydrates.Hāʻawi ia i ka pale koho o nā pūʻulu hydroxyl i loko o nā mole kōpaʻa i ka wā o ka glycosylation reactions, e hiki ai i ka synthesis o nā glycans paʻakikī a me nā glycosides.He mea koʻikoʻi loa kēia hoʻolālā pale i ka kemika carbohydrate, kahi e loaʻa ai nā hui hydroxyl he nui a koi ʻia ka regioselectivity kikoʻī.Hiki ke hoʻohui ʻia ka pūhui i loko o nā hale polymer, e hāʻawi ana i nā wahi reactive no nā hoʻololi hou aʻe a me nā hopena cross-linking.ʻO kēia ka mea e hiki ai ke hana i nā mea polymer me nā waiwai kūpono a me nā hana, e like me ka hoʻomaikaʻi ʻana i ke kūpaʻa, biocompatibility, a me ka hoʻokuʻu ʻana i ka lāʻau hoʻomalu. -((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, a i ʻole TBDMS-protected tetrahydro-2H-pyran-2-one, he pūhui versatile me nā noi like ʻole i ka synthesis organik, ʻoi aku ma ke ʻano he hale kūkulu hale a me ka hui pale. .ʻO kona hiki ke pale pono i nā pūʻulu hana a hoʻomaʻamaʻa i nā hoʻololi molekala paʻakikī e lilo ia i mea waiwai nui ma ke kula kemika.ʻO ka hoʻomau ʻana i ka noiʻi a me ka ʻimi ʻana i kāna mau noi e wehe i nā hoʻohana hou aʻe a kōkua i nā holomua i ka kemika synthetic a me ka ʻepekema waiwai.