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(+)-(3R,5S), tert-Butyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonylamino)-pyrimidin-5-yl]-3,5 ʻO -dihydroxy-6(E)-heptenate, i ʻike ʻia ʻo R1.5 a i ʻole tert-butyl-rosuvastatin, he mea hoʻohui kemika me nā mea hiki ke hoʻohana ʻia i ka ʻoihana lāʻau lapaʻau. nā lāʻau i kapa ʻia he statins.Hana ia ma ke kāohi ʻana i kahi enzyme i kapa ʻia ʻo HMG-CoA reductase, i komo i ka hana ʻana o ka cholesterol i loko o ke kino.ʻO R1.5 kahi derivative o rosuvastatin i loaʻa i kahi pūʻulu tert-butyl i hoʻopili ʻia i ka mole, e hāʻawi ana i nā waiwai hou a me nā pono kūpono.E like me ka rosuvastatin, hiki ke hoʻohana ʻia ka R1.5 e hoʻohaʻahaʻa i nā pae o ka LDL cholesterol, ʻike ʻia hoʻi ʻo "bad" cholesterol, a me nā triglycerides i loko o ke koko.Hiki i kēia pūhui ke hōʻike i nā waiwai pharmacokinetic i hoʻomaikaʻi ʻia, e like me ka hoʻonui ʻana i ka bioavailability a i ʻole ka hoʻonui ʻia ʻana o ke kūpaʻa, ke hoʻohālikelike ʻia me ka lāʻau lapaʻau makua.Eia kekahi, hiki i ka hui tert-butyl ke hāʻawi i ka solubility o ka hui a me ka versatility formulation, i kūpono ia no nā ʻōnaehana lawe lāʻau like ʻole.Hiki i ka pūʻulu tert-butyl ke hana ma ke ʻano he pūʻulu pale, e ʻae ana i ka hoʻokuʻu ʻia ʻana o ka rosuvastatin i loko o nā ʻiʻo a i ʻole nā ​​kino, e like me ke ake.Hiki i kēia hoʻolālā ke hoʻonui i ka maikaʻi o ka lāʻau lapaʻau a hoʻemi i nā hopena ʻaoʻao ma o ka hoʻonui ʻana i kona neʻe ʻana ma ka wahi i hoʻopaʻa ʻia me ka hōʻemi ʻana i ka ʻike ʻana i nā ʻiʻo ʻole.Hāʻawi ke ʻano paʻakikī o ka hui i kahi kahua no nā hoʻololi hou a me nā derivatizations.Hiki i nā mea noiʻi ke hoʻohana i ka R1.5 ma ke ʻano he hui alakaʻi e ʻimi i nā pilina hana-hana a hoʻomohala i nā analogs hou me ka hoʻonui ʻana i ka mana, ke koho, a i ʻole ka hoʻomaikaʻi ʻana i nā profile therapeutic.Hiki i ia mau haʻawina ke kōkua i ka hoʻomohala ʻana i ka moʻolelo a me nā statins ʻoi aku ka maikaʻi a i ʻole nā ​​​​mea hoʻohaʻahaʻa cholesterol. -2-(N-methyl-N-methylsulphonylamino)-pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenate (R1.5 a i ʻole tert-butyl-rosuvastatin) paʻa i ka ʻōlelo hoʻohiki ma ke ʻano he hui lāʻau lapaʻau no ka mālama ʻana i ka hyperlipidemia a me nā maʻi cardiovascular.ʻO kāna hana kūikawā, i hui pū ʻia me ka hui tert-butyl, hiki ke hāʻawi i nā pono e like me ka hoʻomaikaʻi ʻana i ka pharmacokinetics, ka hāʻawi ʻana i ka lāʻau lapaʻau i manaʻo ʻia, a me nā manawa no ka hoʻomohala hou ʻana i ka lāʻau.Pono ka noiʻi hou a me ka hoʻomohala ʻana no ka ʻimi piha ʻana i ka hiki o R1.5 ma ke kahua lāʻau lapaʻau.