Nā huahana

ʻO ka 4-Chloro-2-fluoro-3-methoxyphenylboronic acid he hui kemika i loaʻa nā noi like ʻole i ka synthesis organik, kemika lāʻau lapaʻau, a me ka ʻepekema waiwai. ʻO kekahi o nā hoʻohana mua o 4-Chloro-2-fluoro-3-methoxyphenylboronic acid i ka hoʻololi metala-catalyzed cross-coupling reactions.Hoʻohana ia ma ke ʻano he boronic acid kūkulu hale, e ʻae ai i ka hoʻokumu ʻana i nā paʻa kalapona-carbon a i ʻole carbon-heteroatom.No ka laʻana, hiki ke hoʻohana ʻia kēia pūhui ma Suzuki-Miyaura cross-coupling reactions, kahi e hana ai me ka aryl a i ʻole vinyl halides ma lalo o ka palladium catalysis e hana i nā pūhui biaryl.Hoʻohana nui ʻia kēia mau hoʻohui cross-coupling i ka synthesis o nā molekala organik paʻakikī, me nā lāʻau lapaʻau a me nā agrochemical, a me ke kūkulu ʻana i nā mea kūlohelohe. ʻO -fluoro-3-methoxyphenylboronic acid ka mea e hiki ai i ka synthesis o nā derivatives like ʻole me nā waiwai kūpono.Hiki i ka chlorine atom ke lawelawe ma ke ʻano he hui alakaʻi i nā kaʻina hoʻololi metala-catalyzed, e kuhikuhi ana i ka hopena ma ke koho ʻana i nā wahi kikoʻī i loko o kahi mole.Hāʻawi ka fluorine substitution i ka lipophilicity i hoʻonui ʻia, hiki ke hoʻololi i nā waiwai pharmacokinetic o ka pūhui a hoʻomaikaʻi i kona bioavailability.ʻO ka hui methoxy, ma ka ʻaoʻao ʻē aʻe, hiki ke hana ma ke ʻano he hui pale a i ʻole ke komo ʻana i nā hoʻololi kemika like ʻole. Ma ke kemika lāʻau lapaʻau, ʻo 4-Chloro-2-fluoro-3-methoxyphenylboronic acid a me kāna mau derivatives he mea hoihoi e like me nā moho lāʻau lapaʻau.Hiki i nā pūʻulu hana e like me ka chlorine a me ka fluorine ke hoʻololi i ka pilina o ka pūhui me nā pahuhopu olaola a hoʻomaikaʻi i kāna mau waiwai pharmacological.Eia hou, hiki i ka hui methoxy ke hoʻonui i ka paʻa o ka metabolic o ka hui a kōkua i kona lipophility a me ka solubility.Hana kēia mau waiwai i ka 4-Chloro-2-fluoro-3-methoxyphenylboronic acid i wahi hoʻomaka waiwai no ka hoʻomohala ʻana i nā mea lapaʻau hou i nā kula e like me ka oncology, nā maʻi infectious, a me ka mumū. Hiki i ka -3-methoxyphenylboronic acid ke hoʻokumu i nā esters boronate paʻa, i hoʻohana ʻia i ka hoʻolālā ʻana o nā mea me nā waiwai kūʻokoʻa.Hiki i kēia mau mea ke hōʻike i nā waiwai optical, electronic, a catalytic paha, ma muli o ko lākou haku mele ʻana a me ka hoʻolālā.ʻO ka hoʻohui ʻana o 4-Chloro-2-fluoro-3-methoxyphenylboronic acid a i ʻole nā ​​​​mea i loaʻa i loko o kēia mau mea hiki ke hāʻawi i nā hana kikoʻī a hoʻonui i kā lākou hana. ma muli o kāna kemika maʻamau a me ka hiki ke hana i nā molekala a me nā mea hana.ʻO kāna kuleana i ka hoʻololi ʻana i ka hoʻohui ʻana i ka metala-catalyzed coupling reactions, i hui pū ʻia me nā waiwai kūʻokoʻa o kāna mau pūʻulu hana, lilo ia i mea waiwai nui i ka synthesis organik a me ka lāʻau lapaʻau.Hoʻohui ʻia, hiki i ka boronic acid moiety ke hoʻokumu i nā esters boronate, e kōkua i ka hoʻomohala ʻana i nā mea holomua me nā waiwai i hoʻohālikelike ʻia.