Nā huahana

ʻO ka 4-Chlorophenylboronic acid he pūhui mea ola e loaʻa ai ka hoʻohana ākea ma nā ʻano hana like ʻole, me ka synthesis organik, kemika lāʻau lapaʻau, a me ka ʻepekema waiwai.Aia i loko o kahi apo phenyl i pani ʻia me kahi hui chloro (-Cl) a me kahi hui waikawa boronic (-B (OH) 2). nā hopena hoʻohui keʻa, e like me Suzuki-Miyaura a me Heck reactions.ʻO kēia mau hopena e pili ana i ka hoʻokumu ʻana i nā paʻa kalapona-carbon, kahi e hana ai ka 4-Chlorophenylboronic acid ma ke ʻano he kumu boron e hiki ke hui pū me nā electrophiles organik like ʻole, e like me ka aryl a i ʻole vinyl halides.ʻO kēia ka mea e hiki ai ke hoʻohui i nā pūhui mea ola like ʻole, me nā lāʻau lapaʻau, agrochemical, a me nā mea.No ka laʻana, hiki iā ia ke hana i nā hopena amination e hana i ka 4-chloro-phenylboronates, hiki ke lilo i mau mea waena no ka hoʻohui ʻana i nā pūhui ʻokoʻa i loko o ka nitrogen.Hoʻonui kēia ʻano hui hana i ka pono synthetic o 4-Chlorophenylboronic acid, e ʻae ai i ka hana ʻana i nā molekala paʻakikī me nā waiwai i hoʻopili ʻia.Ua hōʻike ʻo ia i ka ʻōlelo hoʻohiki ma ke ʻano he pharmacophore a i ʻole hale kūkulu hale no ka hoʻomohala ʻana i nā pūhui bioactive.Ma muli o ka boronate moiety, hiki i ka 4-Chlorophenylboronic acid ke hana i nā mea paʻa covalent hiki ke hoʻohuli ʻia me nā molekole i loko o ka diol, e like me nā ʻakika a me nā nucleotides.Ua hoʻohana ʻia kēia pilina e hoʻolālā i nā inhibitor enzyme, nā ligand receptor, a me nā mea lapaʻau ʻē aʻe.No ka laʻana, boronic acid-based proteasome inhibitors ua hoʻomohala ʻia no ka mālama ʻana i nā myeloma lehulehu.Ma ka hoʻohana ʻana i ka hui waika boronic, hiki iā ia ke hana i nā mea paʻakikī hiki ke hoʻohuli ʻia me nā polyols a i ʻole nā ​​pūhui hydroxyl-containing.Hiki ke hoʻohana ʻia kēia waiwai no ka hana ʻana o ka ʻili, e like me ka hoʻokumu ʻana i nā uhi hoʻoulu ʻia a i ʻole ka hoʻomākaukau ʻana i nā mea ʻike no ka ʻike ʻana i nā carbohydrates a i ʻole nā ​​​​mea analytes ʻē aʻe. , a me ka ʻepekema waiwai.ʻO kona hoʻoikaika ʻana i ka hoʻokumu ʻana i ka paʻa kalapona-carbon, hiki ke hoʻokomo i ka pūʻulu hana, a me ka hiki ke hana i nā paʻa covalent reversible e lilo ia i mea hana koʻikoʻi no nā mea noiʻi ma nā ʻano ʻepekema like ʻole.