Nā huahana

ʻO 5-Nitrouracil kahi mea hoʻohui kemika e loaʻa ana ka hoʻohana ʻana i kekahi mau ʻano, me ka lāʻau lapaʻau, biochemistry, a me nā lāʻau lapaʻau.He kumu ia o ka uracil, kahi nucleobase he mea nui o ka RNA. I ka lāʻau lapaʻau, ua hōʻike ʻo 5-Nitrouracil i nā noi hoʻohiki ma ke ʻano he anticancer agent.Hana ia ma ke kāohi ʻana i ka synthesis o DNA a me RNA, a laila ke keʻakeʻa nei i ka ulu a me ka hana hou ʻana o nā maʻi kanesa.Ma ka huli ʻana i nā pūnaewele hoʻokaʻawale wikiwiki, hiki ke hoʻohana ʻia no ka mālama ʻana i nā ʻano maʻi maʻi like ʻole, e like me ka maʻi maʻi colorectal, ka umauma, a me ka ʻōpū.Ua hōʻike pū ʻia ka noiʻi e hiki ke hana maikaʻi ʻo 5-Nitrouracil i ka hui pū ʻana me nā mea hana chemotherapeutic ʻē aʻe, e hoʻonui ana i kā lākou hopena anticancer.Hoʻohana nui ʻia ia ma ke ʻano he molecular probe a i ʻole substrate i nā hoʻokolohua enzyme a me nā noiʻi biochemical.No ka laʻana, hiki ke hoʻohana ʻia e aʻo i nā hopena enzymatic e pili ana i ka metabolism nucleotide, e like me ka hana uracil phosphoribosyltransferase.Ua hoʻohana pū ʻia kona hoʻohui ʻia i loko o nā waikawa nucleic e noiʻi i nā hopena o nā kumu i hoʻololi ʻia i ka hoʻolālā DNA a me ka hana.Loaʻa iā ia nā waiwai e hoʻopaʻa ai i ka UV, hiki ke kōkua i ka pale ʻana i ka ʻili mai ka radiation ultraviolet (UV) ʻino.Loaʻa kēia waiwai mai nā paʻa pālua conjugated i loko o kona ʻano, e ʻae iā ia e komo i ka kukui UV a pale i kona komo ʻana i loko o nā papa hohonu o ka ʻili. pūhui.Hiki ke hoʻohana ʻia ma ke ʻano he precursor i ka hana ʻana i nā lāʻau anticancer a me nā lāʻau lapaʻau ʻē aʻe.ʻO kona loaʻa a me ka hiki ke hoʻokō i nā hopena kemika like ʻole e lilo ia i mea waiwai nui i ka hoʻomohala ʻana i nā lāʻau lapaʻau hou a me nā pūhui therapeutic.ʻO nā hana palekana kūpono, e like me ke komo ʻana i nā mīkina lima a me ka hana ʻana i kahi wahi e hoʻoheheʻe maikaʻi ʻia, pono e hahai ʻia e hōʻemi i ka pilikia o ka ʻike.ʻO kāna mau waiwai anticancer e lilo ia i mea koho no ka mālama ʻana i ka maʻi kanesa, a ʻo kāna mau waiwai biochemical hiki ke hoʻohana ʻia ma ke ʻano he molecular probe a me ka substrate i nā haʻawina enzymatic like ʻole.Hoʻohui ʻia, hoʻonoho ʻia kāna mau mea e hoʻopili ai i ka UV ma ke ʻano he mea hiki ke hoʻohui ʻia i nā ʻano pale sunscreen.Eia kekahi, ʻo kāna hana ma ke ʻano he precursor i ka synthesis o nā pūhui lāʻau lapaʻau e hōʻike ana i kona koʻikoʻi i ka hoʻomohala ʻana i ka lāʻau.He mea koʻikoʻi ka mālama pono ʻana a me ka mālama ʻana i nā kulekele palekana i ka wā e hana ai me 5-Nitrouracil.