Nā huahana

ʻO ka histamine H4 receptor (HRH4), i ʻike ʻia he 13 mau makahiki i hala aku nei, ua manaʻo ʻia he pahuhopu lāʻau lapaʻau maikaʻi no ka maʻi allergy, ʻā, nā maʻi autoimmune a me ka maʻi kanesa, e like me ka hōʻike ʻana e ka nui o nā puke ʻepekema a me nā noi patent.ʻOiai ua ʻike ʻia ka loaʻa ʻana o HRH4 i loko o ka hōʻike, ʻaʻole i hoʻokumu ʻia kona wahi kikoʻī a i ʻole kāna kuleana.Ma ʻaneʻi, ʻimi mākou e ʻike i ke komo ʻana o HRH4 i ka hoʻoponopono ʻana o ka hana cell Leydig.Ua loiloi mua mākou i kona hōʻike ʻana i nā ʻōpū tumora MA-10 Leydig a laila loiloi i nā hopena o ʻelua agonists HRH4 ma ka steroidogenesis a me ka hoʻonui.Ua ʻike mākou ua hōʻike ʻia ʻo HRH4 i loko o nā pūnaewele MA-10, a ʻo kona hoʻāla ʻana e alakaʻi i ka inhibition o LH / kanaka chorionic gonadotropin-induced cAMP production a me StAR protein expression.Eia kekahi, ua ʻike mākou i ka emi ʻana o ka hoʻonui ʻana o ka cell ma hope o kahi mālama agonist 24-h HRH4.A laila ʻike mākou no nā pūnaewele o ka ʻōlelo HRH4 i ka ʻiole maʻamau, a ʻike i ka immunostaining HRH4 i nā cell Leydig o nā ʻiole o 7-240 mau lā, aʻo nā ʻiole he 21 mau lā i hōʻike pū i ka hōʻike HRH4 i nā kāne gametes.ʻO ka mea hope loa, ua loiloi mākou i ka hopena o ka hoʻoulu ʻana o HRH4 i ka hoʻonui ʻana o ka progenitor maʻamau a me ka moʻomeheu ʻo Leydig cell immature, a ua ʻike ʻia ʻelua i ka hopena anti-proliferative o HRH4 agonists.Hāʻawi ʻia i ke koʻikoʻi o ka histamine (2-(1H-imidazol-4-yl) etanamine) i loko o ke kanaka (patho) physiology, hoʻomau ka hoʻoikaika ʻana i ka wehewehe ʻana i nā waiwai e puka mai ana o HRH4 a me kāna mau ligands.Hōʻike kēia haʻawina i nā pūnaewele hou o ka ʻōlelo HRH4, a pono e noʻonoʻo ʻia i ka hoʻolālā ʻana o nā agonists HRH4 koho no nā kumu therapeutic.