Albendazole Cas: 54965-21-8
| Helu Helu | XD91873 |
| inoa mea kūʻai | Albendazole |
| CAS | 54965-21-8 |
| ʻAno Molekalala | C12H15N3O2S |
| Kaumaha Molecular | 265.33 |
| Nā kikoʻī mālama | 2-8°C |
| Kānāwai Kūʻai Kūlike | 29332990 |
Huahana Huahana
| Ka nana aku | ʻO ka pauka kristal keʻokeʻo |
| ʻO Assay | 99% min |
| Lae hehee | 208-210 °C |
| mānoanoa | 1.2561 (manaʻo koʻikoʻi) |
| hōʻike hoʻopaʻapaʻa | 1.6740 (manaʻo) |
| hikiwawe | ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i loko o ka anhydrous formic acid, hiki ke hoʻoheheʻe iki ʻia i ka methylene chloride, hiki ʻole ke hoʻoheheʻe ʻia i ka ethanol (96 pākēneka). |
| pka | 10.72±0.10(Wanamua) |
| Hiki i ka wai | 0.75mg/L(209 ºC) |
ʻO Albendazole kahi lāʻau lapaʻau i hoʻohana ʻia e mālama i nā maʻi i hana ʻia e nā parasites.Hiki ke hāʻawi ʻia no ka mālama ʻana i kahi maʻi lolo kakaʻikahi (neurocysticercosis) a i ʻole hiki ke hāʻawi ʻia no ka mālama ʻana i kahi maʻi parasitic e kumu ai ka maʻi maʻi nui (microsporidiosis).
ʻO kahi derivative o benzimidazole, ʻo albendazole kahi lāʻau lapaʻau me kahi ākea antihelmintic spectrum.Hōʻike ia i kahi hopena antihelmintic e kūʻē i nā cestodes a me nā nematodes ma ke kāohi ʻana i ke kaʻina o ka lawe ʻana o ka glucose e nā parasites, i hōʻike ʻia i ka hoʻopau ʻana o nā mālama glycogen a me ka hoʻohaʻahaʻa ʻana i ke kiʻekiʻe o ka adenosintriphophate.ʻO ka hopena, pau ka neʻe ʻana o ka parasite a make.Hoʻohana ʻia ia i ka maʻi o Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, a me Trichuris trichiura.ʻO nā inoa like o kēia lāʻau lapaʻau ʻo SKF 62979 a me nā mea ʻē aʻe.
ʻO ka Methyl 5-(propylthio) -2-benzimidazolecarbamate (Eskazole, Zentel) kahi lāʻau anthelmintic ākea ākea ʻaʻole i kūʻai ʻia i kēia manawa ma ʻAmelika ʻĀkau.Loaʻa ia mai ka mea hana ma ke kumu hoʻohana aloha.Hoʻohana nui ʻia ʻo Albendazole ma ka honua holoʻokoʻa no ka mālama ʻana i ka maʻi intestinalnematode.He kūpono ia ma ke ʻano he lāʻau lapaʻau hoʻokahi no ka ascariasis, nā maʻi hookworm New and Old World, a me trichuriasis.ʻO ka lāʻau lapaʻau nui me ka albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, a me ka maʻi hydatid.ʻO ka maikaʻi o ka albendazole e kūʻē i nā ilo lipi (cestodes) maʻamau ʻoi aku ka loli a me ka liʻiliʻi.
Hana ʻia ʻo Albendazole ma ke ʻano he pauka crystalline keʻokeʻo i hiki ʻole ke hoʻoheheʻe ʻia i ka wai.Hoʻonui ʻia ka ʻai waha o ka albendazole e ka ʻai momona.Hoʻomaka ka lāʻau lapaʻau me ka wikiwiki a me ka nui o ka metabolism mua i ka sulfoxide, ʻo ia ke ʻano ikaika i ka plasma.ʻO ka hapalua o ke ola o ka sulfoxide mai 10 a 15 mau hola.He nui ka biliary excretion a me ka hana hou enterohepatic o albendazolesulfoxide.ʻAʻole ʻae ʻia ʻo Albendazole i ka lāʻau hoʻokahi-dose no nā nematodes ʻōpū.ʻO ka lāʻau kiʻekiʻe, ka lāʻau lōʻihi e pono ai no ka maʻi clonorchiasis orechinococcal therapy hiki ke hopena i nā hopena ʻino e like me ke kaumaha o ka iwi iwi, ke kiʻekiʻe o nā enzyme hepatic, a me ka alopecia.
ʻO Albendazole ka nui o ka hana e kū'ē i nā nematodes a me nā cestodes o ka'ōpū, a me ke akepaʻa o Opisthorchis sinensis, Opisthorchis viverrini, a me Clonorchis sinensis.Ua hoʻohana maikaʻi ʻia e kūʻē iā Giardia lamblia.He lāʻau maikaʻi ʻo Albendazole i ka maʻi hydatid cyst (echinococcosis), ʻoi aku ka nui o ka wā i hui pū ʻia me praziquantel.He mea maikaʻi nō hoʻi ia i ka mālama ʻana i ka neurocysticercosis cerebral a me spinal, ʻoiai ke hāʻawi ʻia me ka dexamethasone. Manaʻo ʻia ʻo Albendazole no ka mālama ʻana i ka gnathostomiasis.
