Nā huahana

Ua hoʻohana ʻia ʻo Chitosan-dextran gel ma ke ʻano he antihemostatic agent a me ka antiadhesive agent ma hope o ke kaʻina endoscopic sinus.No ka mea ua hoʻopili ʻia nā biofilms Staphylococcus aureus i ka rhinosinusitis maʻi recalcitrant, ua manaʻo kēia noiʻi e noiʻi hou i ka (i) anti-inflammatory, (ii) inhibition biofilm bacterial, (iii) nā hopena antiproliferative, a (iv) nā waiwai hoʻōla ʻeha o chitosan a chitosan-dextran gel. Ua hoʻokaʻawale ʻia nā fibroblasts mai ka ihu kanaka a ua hoʻohana ʻia no ka hoʻoholo ʻana i nā hopena o ka chitosan a me ka chitosan-dextran gel ma (i) ka hoʻonui ʻana o nā cell, (ii) hoʻōla ʻeha, (iii) ʻā i nā moʻomeheu fibroblast i hoʻokūkū ʻia me nā superantigens S. .aureus enterotoxin B (SEB) a me ka toxic shock syndrome toxin (TSST), a me (iv) ma S. aureus biofilms. Ua hana maikaʻi loa ʻo Chitosan i ka hōʻemi ʻana i ka ʻōlelo IL-8 ma hope o ka hoʻokūkū TSST a me SEB.Ua maikaʻi nō hoʻi ʻo Chitosan i ka hōʻemi ʻana i ka hōʻike IL-8 o nā fibroblasts nochallenged e hōʻike ana i kāna mau hopena anti-inflammatory ma nā fibroblasts i kahi kūlana iseased.Ua hōʻike ʻo Chitosan-dextran gel i nā waiwai antibiofilm ikaika ma 50% (v / v) ka nui o ka in vitro.ʻO Dextran, ma kāna iho, hōʻike i nā waiwai antibiofilm ma 1.25% (w / v) hoʻonui.ʻO Chitosan, ma kāna iho, hoʻemi i ka hoʻonui ʻana o nā fibroblasts i 82% o ka hoʻonui ʻana i ka mana a me ka chitosan-dextran gel i hoʻemi i ka hoʻonui ʻana o nā fibroblasts i 0.04% o ka hoʻonui ʻana.E pili ana i ka mālama ʻole ʻana, ua hoʻopaneʻe nui ka chitosan-dextran gel i ka wikiwiki o ka hōʻeha ʻana i nā hola 48 mua o ka hoʻokolohua. manawa.Ua hōʻemi ʻo Chitosan i nā pae IL-8, e hōʻike ana i kāna mau waiwai anti-inflammatory.Ua hōʻike ʻo Chitosan-dextran gel a me dextran i nā waiwai antibiofilm i kā mākou kumu hoʻohālike.