Nā huahana

ʻO Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride he mea hoʻohui kemika i hoʻohana mau ʻia i ka noiʻi lāʻau lapaʻau a me ka hoʻomohala lāʻau.ʻO kona ʻano molekala he pūʻulu benzyl i hoʻopili ʻia i kahi hui hana carbamate ma o ka piperidine moiety. a i ʻole waena i ka synthesis o nā pūhui lāʻau like ʻole.ʻO ka hele ʻana o ke apo piperidine e hāʻawi i kēia pūhui me ka versatility i nā hopena kemika organik, e lilo ia i mea hoʻomaka waiwai no ka synthesis o nā molekala paʻakikī.Ma ka hoʻokomo ʻana i kēia pūhui i loko o kahi ala synthetic, hiki i nā chemists ke komo i kahi ākea o nā pūhui hou me nā noi therapeutic hiki ke hoʻohana ʻia. he hale kūkulu hale no ka hoʻomohala ʻana i nā lāʻau hou e kuhikuhi ana i nā ala olaola a i ʻole nā ​​​​mea hoʻokipa.ʻO kāna mau hiʻohiʻona hoʻolālā e kūpono ia no ka hoʻopili ʻana i loko o nā molekala lāʻau, e hana ana ma ke ʻano he pharmacophore a i ʻole kahi hui hana koʻikoʻi no ka hana i makemake ʻia.Ma ka hoʻololi ʻana i nā ʻāpana benzyl, piperidine, a i ʻole carbamate, hiki i nā mea noiʻi ke hoʻopaʻa i ka mana o ka lāʻau, koho, a me nā waiwai pharmacokinetic. Hiki ke hoʻohana ʻia ka pūhui ma ke ʻano he mea hana a i ʻole pūhui kuhikuhi no ka ʻike ʻana i ka lāʻau a me nā haʻawina hoʻolālā-activity (SAR).Ma ka hoʻohālikelike ʻana i ka hana olaola o nā derivatives like ʻole a i ʻole nā ​​analogs o Benzyl N-[2-(piperidin-4-yl) propan-2-yl]carbamate hydrochloride, hiki i nā mea noiʻi ke loaʻa nā ʻike i ka pilina hana-hana, e ʻae iā lākou e hoʻolālā i ʻoi aku ka ikaika. a me nā hui koho.He mea koʻikoʻi kēia ʻike no ka hoʻonui ʻana i nā pūhui alakaʻi a me ka hoʻomohala ʻana i nā moho lāʻau lapaʻau ʻoi aku ka maikaʻi. e aʻo i ke ʻano o ka hana o kekahi mau lāʻau a i ʻole e noiʻi i ka metabolism lāʻau.Ma o ka hoʻohana ʻana i nā mana radiolabeled a i hoʻopaʻa ʻia paha o kēia pūhui, hiki i nā mea noiʻi ke nānā i kona hoʻolaha ʻana a me ka metabolism i loko o nā ʻōnaehana olaola.Kōkua kēia ʻike i ka hoʻomaopopo ʻana i ke ʻano o ka hana ʻana a me ka hoʻokuʻu ʻia ʻana o nā lāʻau i loko o ke kino, e hāʻawi ana i nā ʻike koʻikoʻi e pili ana i ka pili ʻana i ka lāʻau lapaʻau, nā regimens dosage, a me nā pilina lāʻau-lāʻau. ʻO ka 2-yl] carbamate hydrochloride kahi mea hoʻohui i hoʻohana nui ʻia i ka noiʻi lāʻau lapaʻau a me ka hoʻomohala ʻana i ka lāʻau.ʻO kāna mau hiʻohiʻona hoʻolālā he mea waiwai ia ma ke ʻano he precursor no ka synthesis o nā pūhui lāʻau like ʻole a ma ke ʻano he hale kūkulu no ka hoʻomohala ʻana i nā lāʻau lapaʻau hou.Eia kekahi, lawelawe ia ma ke ʻano he mea hana no nā haʻawina SAR, ʻike lāʻau lapaʻau, a me ka noiʻi metabolism.ʻO nā noi like ʻole o Benzyl N-[2-(piperidin-4-yl) propan-2-yl]carbamate hydrochloride e hōʻike ana i kona koʻikoʻi i ka hoʻomohala ʻana i nā mea lapaʻau hou a me ka holomua o ka lāʻau lapaʻau.