Nā huahana

ʻO ka thrombin-activatable fibrinolysis inhibitor (TAFIa) he zinc-containing carboxypeptidase a keʻakeʻa nui nei i ka fibrinolysis.No laila, manaʻo ʻia nā mea hoʻopale TAFIa e hana ma ke ʻano he profibrinolytic agents.Ua hōʻike koke aku nei mākou i ka hoʻolālā a me ka synthesis o nā mea hoʻopaneʻe selenium i loko o TAFIa a me kā lākou hana pale.Ma ʻaneʻi, hōʻike mākou i nā ʻano hana aniani o ka potent selenium-, sulfur-, a me ka phosphinic acid-containing inhibitors i hoʻopaʻa ʻia i ka porcine pancreatic carboxypeptidase B (ppCPB).ʻO ppCPB kahi homologue TAFIa a ua pani ʻo TAFIa no ka nānā ʻana i ka crystallographic.Ua hoʻoholo ʻia nā hale aniani o ka ppCPB me ka pūhui selenium 1a, kona sulfur analogue 2, a me ka phosphinic acid derivative EF6265 ma 1.70, 2.15, a me 1.90 Å hoʻonā.Hoʻopaʻa ʻia kēlā me kēia mea paʻa i ka pūnaewele ikaika o ppCPB ma ke ʻano like me ka mea i ʻike ʻia no nā mea hoʻopaneʻe i hōʻike mua ʻia.No laila, i loko o nā complexes, selenium, sulfur, a me ka phosphinic acid oxygen coordinate i ka zinc ma ppCPB.ʻO kēia ka ʻike mua a me ka hōʻike o ka hui pū ʻana o selenium i ka zinc ma CPB.