Nā huahana

ʻO Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride he mea hoʻohui kemika i loaʻa ka noi ma ke kahua o ka lāʻau kemika a me ka hoʻomohala ʻana i ka lāʻau.He apo pyrrolidine kona ano mole me ka hui tert-butyl ma ke kulana cis, he hui ethyl, a me elua hui carboxylate.Loaʻa ʻia kēia pūhui ma ke ʻano o ka paʻakai hydrochloride. ʻO kekahi o ka hoʻohana nui ʻana o cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride i ka synthesis a me ka hoʻomohala ʻana i nā lāʻau lapaʻau e kuhikuhi ana i ke kikowaena. ʻōnaeʻa makaʻu (CNS).ʻO ka loaʻa ʻana o ke apo pyrrolidine, me nā pūʻulu tert-butyl a me ethyl, hāʻawi i kēia pūhui me nā waiwai neuroactive.Hiki i nā mea noiʻi ke hoʻohana i kēia pūhui ma ke ʻano he mea hoʻomaka e synthesize i nā analogs a i ʻole derivatives i hiki ke koho koho me nā mea loaʻa a i ʻole nā ​​enzyme i loko o ka CNS.Ma ka hoʻololiʻana i ka hale a me nā mea pani, hiki iā lākou ke hoʻonui i ka waiwai pharmacokinetic o ka pūhui, e hoʻonui i kona pilina pili, a hoʻonui i kona hiki ke hoʻoponopono. Hoʻohana ʻia ma ke ʻano he mea hana i nā haʻawina biological e noiʻi i ke kuleana o nā mea loaʻa a i ʻole nā ​​enzyme i nā kaʻina neurological.Ma ka hoʻohana ʻana i kēia pūhui ma ke ʻano he ligand a i ʻole ka ʻimi noiʻi, hiki i nā mea noiʻi ke aʻo i ka pilina paʻa, ke koho ʻana, a me ke ʻano o ka hana o kēia mau mea loaʻa a i ʻole nā ​​enzymes.He mea koʻikoʻi kēia ʻike no ka hoʻomaopopo ʻana i ke kumu molekula o nā kaʻina neuropharmacological a no ka hoʻomohala ʻana i nā therapeutics novel e kuhikuhi ana i nā maʻi neurodegenerative, nā kūlana psychiatric, a i ʻole nā ​​maʻi neurological.Hiki ke hoʻohui ʻia i loko o nā hale waihona puke o nā pūhui, i hoʻopaʻa ʻia e kūʻē i nā pahuhopu like ʻole, e like me nā mea hoʻokipa a i ʻole nā ​​enzymes, e ʻike ai i nā pūhui alakaʻi a i ʻole nā ​​​​moho lāʻau.Hiki i kēia kānana ke ʻike i nā pūhui e hōʻike ana i nā waiwai pharmacological i makemake ʻia a i ʻole nā ​​​​hopena therapeutic hiki ke loaʻa.ʻO nā prodrugs he mau pūhui hana ʻole a liʻiliʻi paha i hoʻolālā ʻia e hoʻololi ʻia i ko lākou ʻano hana i hoʻokahi manawa i loko o ke kino.Ma ka hoʻololi ʻana i ke ʻano o kēia pūhui, hiki i nā mea noiʻi ke hana i nā ʻano prodrug i ʻoi aku ka paʻa, ua hoʻomaikaʻi i ka bioavailability, a i ʻole hiki ke hele maʻalahi i nā membrane biological.Hiki i kēia ke hoʻonui i nā pono therapeutic o ka pūhui a hoʻomaikaʻi i kāna mau waiwai pharmacokinetic. I ka hōʻuluʻulu ʻana, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride he hui me nā noi kūpono i ka hoʻomohala ʻana i nā lāʻau lapaʻau CNS-targeted. , ma ke ʻano he mea hoʻohui no nā haʻawina olaola, i ka ʻike ʻana i ka lāʻau, a i ka hoʻomohala ʻana i nā prodrugs.Hāʻawi kona ʻano molekala kūʻokoʻa i nā manawa kūpono no ka hoʻololi ʻana a me ka optimization e hoʻomaikaʻi i kāna mau waiwai pharmacological a me nā hana biological.ʻO ka versatility a me ka hiki o kēia pūhui e lilo ia i mea waiwai nui ma ke kahua o ka lāʻau kemika a me ka hoʻomohala lāʻau.