Nā huahana

ʻO Citicoline (CDP-choline) kahi mea hoʻolaha nui i ka biosynthesis o phosphatidylcholine, kahi mea nui o ka membrane cell neural.Ua hōʻike ʻia e hana i nā hopena maikaʻi ma nā ʻano holoholona ʻelua a me nā hoʻāʻo ʻana i ka maʻi maʻi maʻi non-US.Aia kēia haʻawina i kahi randomized (3 doses of citicoline to 1 placebo), kaʻa-controlled, double-blind hoʻokolokolo ma 21 US centers.Hoʻomaka ka lāʻau lapaʻau i loko o 24 mau hola ma hope o ka hoʻomaka ʻana o ka hahau ʻana a hoʻomau ʻia ma ka waha no 6 pule.ʻO nā loiloi hopena hope loa ma 12 pule.ʻElua haneli kanalimakumamāiwa mau maʻi i kākau inoa ʻia, me kahi o 65 i kēlā me kēia o nā hui ʻehā.ʻO ka manawa maʻamau mai ka hoʻomaka ʻana o ka hahau a hiki i ka mālama ʻana he 14.5 mau hola, a ʻaʻohe ʻokoʻa koʻikoʻi o nā ʻano kumu ma waena o nā pūʻulu ʻehā koe wale nō ka kaumaha maʻi.Ua ʻike ʻia kahi ʻokoʻa nui ma waena o nā hui, makemake i ka lāʻau citicoline, ma ke ʻano o ka hopena hana e like me ke ana ʻana e ka Barthel Index a me Rankin scale, neurologic loiloi e like me ke ana ʻana e ka National Institutes of Health (NIH) stroke scale, a me ka hana cognitive e like me ke ana ʻana. ka Mini Mental Status Examination.I ka wā i hoʻohana ʻia ai ka baseline NIH stroke scale ma ke ʻano he covariate, ʻo ka hui 500-mg citicoline a me ka hui citicoline 2,000-mg i hoʻomaikaʻi nui ʻia ma ke ʻano o ka pakeneka o nā maʻi i loaʻa ka hopena maikaʻi ma ka Barthel Index ma 90 mau lā.ʻAʻohe hanana ʻino koʻikoʻi e pili ana i ka lāʻau a make paha i loko o kēia haʻawina.Hōʻike kēia haʻawina e hiki ke hoʻohana pono ʻia ka citicoline waha me ka liʻiliʻi o nā hopena ʻaoʻao i ka mālama ʻana i ka hahau.ʻIke ʻia ʻo Citicoline e hoʻomaikaʻi i ka hopena hana a hōʻemi i ka deficit neurologic me 500 mg o citicoline i ʻike ʻia ʻo ia ka hopena maikaʻi loa.