Nā huahana

Cardioprotectant: ʻO Creatine phosphate he mea waiwai nui e hoʻolako i ka ikehu i ka ʻoki ʻana o ka ʻiʻo a me ka metabolism.ʻO ia ka waihona ikehu kemika o ka ʻiʻo maʻemaʻe a me ka ʻiʻo striated, a hoʻohana ʻia no ka resynthesis ATP.ʻO Phosphocreatinedisodium kona ʻano lāʻau lapaʻau.ʻO Sodium Creatine Phosphate, inoa kemika N-[imino(phosphono)methyl]-N-methylglycine disodium paʻakai, he mea hana cardioprotective i hoʻokuʻu ʻia e Italian Ouhui Pharmaceutical Factory ma 1992. ʻO ke ʻano phosphocreatine e pāʻani i nā ʻano hana physiological koʻikoʻi, a hoʻohana nui ʻia. no ka pale ʻana i ka myocardial i nā poʻe maʻi me ka ischemia cardiac a i ka wā o ka ʻoki ʻana i ka puke Chemicalbook cardiac, a no ka mālama ʻana i nā maʻi cardiovascular e like me ka puʻuwai puʻuwai, myocardial infarction a me arrhythmia.Hiki iā ia ke hoʻomaikaʻi i ka hana naʻau a me ka loli o ka puʻuwai i nā maʻi me ka ischemic cardiomyopathy.ʻAʻole hiki iā ia ke hāʻawi wale i ka ikehu no nā cell myocardial i ka wā e loaʻa ai lākou i ka ischemia a me ka hypoxia, akā pale pū kekahi i nā membrane cell myocardial mai ka hoʻouka ʻana o nā radical free oxygen a me nā mea ʻino ʻē aʻe, hiki ke hoʻopilikia i ka hana cardiac.ʻO ka pale o ka myocardial postoperative i nā poʻe maʻi me ka maʻi valvular incompetent he mea maikaʻi i ka hoʻihoʻi ʻana o ka hana puʻuwai postoperative i nā maʻi me ka maʻi valvular incompetent.ʻO ka hoʻohana ʻana iā ia no ka mālama piha ʻana i ka pōʻino myocardial ma hope o ka asphyxia neonatal hiki ke hoʻomaikaʻi maikaʻi i ka myocardial enzymes a me ka electrocardiogram, a he hopena curative maikaʻi a palekana.

Nā hiʻohiʻona hana ʻO kēia huahana ka mālama ʻana i ka ikehu kemika o ka puʻuwai a me nā ʻiʻo iwi, a hoʻohana ʻia no ka resynthesis o ATP, e hāʻawi ana i ka ikehu no ke kaʻina hana o ka actomyosin contraction, a he hana koʻikoʻi i ka metabolism ikehu o ka ʻoki ʻana o ka ʻiʻo.ʻO ka lawaʻole o ka ikehu he mea nui ia i ka hoʻokumu ʻana a me ka hoʻomohala ʻana o ka hōʻeha o ka myocardial cell.

1. He hopena pale koʻikoʻi ia i ka hana systolic myocardial ischemic, hiki ke hoʻihoʻi piha i ka contractility a hoʻemi wikiwiki i ke koko diastolic.

2. E mālama i ka maʻiʻo o ka adenosine triphosphate a me ka creatine phosphate i loko o nā pūnaewele, a mālama ʻo Chemicalbook i ka mālama ʻana i ka ikehu myocardial.

3. Hoʻemi i ka nalowale o ka creatine kinase a hoʻemi i ka pōʻino o ka membrane cell.

4. Loaʻa iā ia nā waiwai anti-peroxidation.

5. Hoʻonui i ka microcirculation myocardial.Ma muli o ka loaʻa ʻana o nā mea hoʻopaʻa phosphate kiʻekiʻe i loko o nā molekala creatine phosphate, hiki i nā mea hoʻopaʻa phosphate kiʻekiʻe ke hoʻololi pololei i ka ADP i ATP ma lalo o ka hana o ka creatine phosphate, a hāʻawi pololei i ka ikehu i ke kino e hana koke.Ma ke ʻano he huahana waena o ka glycolysis, pono e pāʻani ka sodium fructose diphosphate i kahi kuleana ma o ka anaerobic metabolism.

ala synthetic:

1 Me ka hoʻohana ʻana i ka dibenzyl phosphate ma ke ʻano he mea maka, e hana me ka oxalyl chloride e loaʻa ai ka dibenzyl oxyphosphoryl chloride,

2 Ma lalo o ka hana a triethylamine, ua hoʻololi ʻia ka dibenzyloxyphosphoryl creatine ethyl ester i loaʻa ma ka hopena me ka creatine ethyl ester hydrochloride i ka dibenzyloxyphosphoryl creatinine,

3. Ma hope o ka palladium carbon catalyzed hydrogenolysis i debenzylate, e hana me ka sodium hydroxide e loaʻa ai ka disodium creatinine phosphate,

Hoʻopili ʻia ka 4 i ka 1 ma lalo o ka hana o ka sodium hydroxide.

Hoʻohana: He kūpono ia no ka pale ʻana i ka myocardial metabolism ma ke ʻano o ka myocardial ischemia.

ʻO nā hopena ʻino, contraindications a me nā hopena lāʻau: pāpā ʻia ka poʻe maʻi i nā ʻāpana o kēia huahana;ʻAʻole ʻae ʻia ka poʻe me ka hemahema o ka renal mai ka hoʻohana ʻana i nā ʻano nui (5-10g/d).Hiki ke hoʻemi ʻia ke kahe koko ma mua o 1g.ʻO ka hoʻokele kiʻekiʻe ka hopena i ka lawe ʻana i ka phosphate kiʻekiʻe, hiki ke hoʻopilikia i ka metabolism calcium a me ka huna ʻana o nā hormones e hoʻoponopono i ka homeostasis, e pili ana i ka hana renal a me ka purine metabolism.