Nā huahana

Hōʻike ʻia kahi palapala e puka mai nei e hiki i ka bisphenol A (BPA), kahi mea hoʻopōʻino endocrine ākea, ke ʻike ʻia i ka wā ʻōpiopio, hiki ke hoʻonui i ka pilikia o ka metabolic syndrome.Ma kēia noiʻi ʻana, ua noiʻi mākou i ke kuhiakau e pili ana i ka ʻike perinatal i ka BPA predisposed nā keiki i ka maʻi ate momona: ka hōʻike hepatic o ka metabolic syndrome, a me kāna hana hiki.Hāʻawi ʻia nā ʻiole Wistar hāpai me ka BPA (40μg / kg / lā) a i ʻole kaʻa i ka wā hāpai a me ka lactation.Ua nānāʻia ka moʻolelo o ka ate, ka biochemical analysis, transcriptome, a me ka hana mitochondrial i nā keiki kāne ma ka postnatal 3, 15 a me 26 wiki.I nā wiki he 3, ʻaʻole i ʻike ʻia ka morphology o ka ate a me ka hana ʻana i ka BPA-exposed offspring, akā ʻo ka emi ʻana o ka hana mitochondrial respiratory complex (MRC) (I a me III) a me nā loli koʻikoʻi i ka hōʻike gene i komo i ka mitochondrial fatty acid metabolism. nānā ʻia i hoʻohālikelike ʻia me nā mana.Ma 15 pule, micro-vesicular steatosis i loko o ke akepaʻa, up-re gulated genes komo i loko o lipogenesis ala, hoʻonui ROS hanauna a me Cytc hoʻokuʻu i nānā 'ia i loko o ka BPA-i ikeia keiki.A laila, ʻike ʻia ka nui o ka momona i loko o ke akepaʻa a me ka serum ALT kiʻekiʻe i nā keiki i hōʻike ʻia i ka BPA i nā pule he 26.I ka nānā ʻana i ka lōʻihi, ua hoʻonui ʻia ka hana mitochondrial hepatic me ka hana MRC, ka hana ATP, ka hana ROS a me ka hiki o ka membrane mitochondrial i nā keiki i hōʻike ʻia i ka BPA.ʻO ka hoʻolaha ʻana o ka BPA Perinatal e kōkua i ka hoʻomohala ʻana o ka steatosis hepatic i nā hua o nā ʻiole, hiki ke hoʻopili ʻia ma o ka hana mitochondrial hepatic impaired a me ka up-regulated hepatic lipid metabolism.