D-Leucine Cas: 328-38-1 99% ʻO ka pauka keʻokeʻo
| Helu Helu | XD90305 |
| inoa mea kūʻai | D-Leucine |
| CAS | 328-38-1 |
| ʻĀpana Molekala | C6H13NO2 |
| Kaumaha Molecular | 131.17292 |
| Nā kikoʻī mālama | Ambient |
| Kānāwai Kūʻai Kūlike | 29224985 |
Huahana Huahana
| Kahuli kiko'ī | -14 a i -16 |
| AS | <1ppm |
| Pb | <10ppm |
| Nalo ma ka maloo | <0.20% |
| Hoʻāʻo | 99% |
| Koena ma ka Ignition | <0.10% |
| Cl | <0.020% |
| Ka nana aku | Pauda keʻokeʻo |
ʻO nā kumu o ke kaiapuni, e like me ka macronutrient composition o ka meaʻai, hiki ke loaʻa ka hopena nui i ka hopena o ka maʻi diabetes a me ka metabolic syndrome.Ma ka haʻawina i kēia manawa, hōʻike mākou i ke ʻano o ka meaʻai maʻalahi hoʻokahi--leucine--hiki ke hoʻololi i ka pale ʻana o ka insulin ma ka hana ʻana i nā ʻiʻo he nui a ma nā pae he nui o ka metabolism.Hoʻokomo ʻia nā ʻiole ma kahi meaʻai maʻamau a momona momona (HFD).Ua pāpālua ʻia ka leucine meaʻai ma ka hoʻohui ʻana i ka wai inu.Ua loiloi ʻia ka mRNA, protein a me nā profile metabolomic piha i nā ʻiʻo nui a me ka serum insulin, a hoʻopili ʻia me nā loli i ka homeostasis glucose a me ka hōʻailona insulin.Ma hope o 8 mau pule ma ka HFD, ua hoʻomohala nā ʻiole i ka momona, ka momona momona, nā hoʻololi ʻana i ka ʻiʻo adipose a me ke kūpaʻa ʻana o ka insulin ma ke kiʻekiʻe o IRS-1 phosphorylation, a me nā hoʻololi i ka metabolomic profile of amino acid metabolites, TCA cycle intermediates, glucose and cholesterol metabolites , a me nā ʻakika momona i loko o ke ake, ka ʻiʻo, ka momona a me ka serum.ʻO ka hoʻopalua ʻana i ka leucine meaʻai i hoʻihoʻi i ka nui o nā mea ʻino o ka metabolite a ua hoʻomaikaʻi maikaʻi ʻia i ka hoʻomanawanui glucose a me ka hōʻailona insulin me ka hoʻololi ʻole i ka ʻai ʻana a i ʻole ka piʻi paona.Ua pili pū ka hoʻonui ʻana i ka leucine meaʻai me ka emi ʻana o ka steatosis hepatic a me ka emi ʻana o ka mumū i ka ʻiʻo adipose.Ua loaʻa kēia mau hoʻololi ʻoiai ka piʻi ʻana o ka phosphorylation i hoʻoulu ʻia e ka insulin o p70S6 kinase e hōʻike ana i ka hoʻonui ʻia ʻana o ka mTOR, kahi mea maʻamau e pili pū me ke kūʻē ʻana o ka insulin.Hōʻike kēia mau ʻikepili e hiki i nā loli haʻahaʻa i kahi mea kaiapuni / meaʻai meaʻai ke hoʻololi i nā ala metabolic a me nā ala hōʻailona a hoʻololi i ka maʻi metabolic i hoʻokomo ʻia i ka HFD ma o ka hana ʻana ma kahi pae ʻōnaehana ma nā kiko he nui.Hōʻike pū kēia mau ʻikepili i ka hoʻonui ʻana i ka leucine meaʻai hiki ke hāʻawi i kahi mea hoʻohui i ka hoʻokele ʻana i ka pale ʻana o ka insulin pili i ka momona.
