Dirhodium tetraacetate CAS:15956-28-2 99% ʻeleʻele ʻōmaʻomaʻo
| Helu Helu | XD90641 |
| inoa mea kūʻai | ʻO Dirhodium tetraacetate |
| CAS | 15956-28-2 |
| ʻĀpana Molekala | C8H12O8Rh2 |
| Kaumaha Molecular | 441.987 |
| Nā kikoʻī mālama | Ambient |
| Kānāwai Kūʻai Kūlike | 28439000 |
Huahana Huahana
| Ka nana aku | Nā aniani ʻōmaʻomaʻo-ʻeleʻele |
| Hoʻāʻo | 99% |
ʻO ka N7/O6 equatorial hoʻopaʻa ʻana o ka antitumor active complex Rh(2)(OAc)(4)(H(2)O)(2) (OAc(-) = CH(3)CO(2)(-)) me ka ʻāpana DNA d(GpG) ua hoʻoholo maopopo ʻia e ka NMR spectroscopy.ʻO nā hoʻoholo crystallographic X-ray mua o ke poʻo-a-poʻo (HH) a me ke poʻo-i-huelo (HT) hoʻohui ʻia o ka dirhodium tetraacetate me 9-ethylguanine (9-EtGH) i hōʻike ʻia i ka hui ʻana o N7/O6 guanine nucleobases e holo ana i ka Rh. - Rh pili.ʻO ka nele o ka protonation N7 ma ka pH haʻahaʻa a me ka piʻi nui ʻana o ka acidity o N1-H (pK(a) ma kahi o 5.7 ke hoʻohālikelike ʻia me 8.5 no N7 wale nō i hoʻopaʻa ʻia i ka platinum adducts), i manaʻo ʻia e nā titrations hilinaʻi pH o ka purine H8 (1). )H NMR no Rh(2)(OAc)(2)(9-EtG)(2) a me Rh(2)(OAc)(2-)[d(GpG)], ua kūlike me ka bidentate N7/O6 paʻa. o ka guanine nucleobases.ʻO nā koina pK(a) i manaʻo ʻia no ka protonation N1-H (de), mai nā haʻawina pili pH o ka C6 a me C2 (13)C NMR resonances no ka Rh(2)(OAc)(2)(9-EtG)( 2) isomers, e like me ka t hose i loaa mai ka H8 (1)H NMR resonance titrations.Ka hoʻohālikelike o ka (13)C NMR resonances o C6 a me C2 no ka dirhodium hoʻohui Rh(2)(OAc)(2)(9-EtG)(2) a me Rh(2)(OAc)(2)[d(GpG) )] me nā resonances like o nā ligands unbound [ma pH 7.0 no 9-EtGH a me pH 8.0 no d(GpG)], e hōʻike ana i nā hoʻololi nui o Deltadelta ma kahi o 11.0 a me 6.0 ppm no C6 a me C2;ʻO nā hoʻololi hope e hōʻike i ka hopena o ka hoʻopaʻa ʻana o O6 i nā kikowaena dirhodium a me ka hoʻonui ʻana i ka acidity o N1-H.Hōʻike ʻia ka hoʻonohonoho poʻo-a-poʻo o nā kumu guanine ka H8/H8 ROE koʻikoʻi i ka 2D ROESY NMR spectrum o Rh(2)(OAc)(2)[d(GpG)].Hōʻike ka Rh(2)(OAc)(2)[d(GpG)] i nā mea hoʻohui lima ʻākau nui, HH1 R a me HH2 R, me ka HH1 R ʻekolu manawa ʻoi aku ka nui ma mua o ka HH2 R ʻokoʻa. Ua hōʻike ʻia nā mea hoʻohui i ka repuckering o nā apo kō 5'-G i C3'-endo (N-type), ka paʻa ʻana o C2'-endo (S-type) conformation no ka 3'-G sugar ring gs, a me ka anti orientation e pili ana i ka nā paʻa glycosyl.ʻO nā hiʻohiʻona kūkulu i loaʻa no Rh(2)(OAc)(2))[d(GpG)] ma o ka NMR spectroscopy ua like loa me nā mea no cis-[Pt(NH(3))(2))[d( GpG)]] a kākoʻo i nā haʻawina hoʻohālike molekala.
