Nā huahana

ʻO ka Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate he mea hoʻohui kemika i loaʻa nā noi i nā ʻano like ʻole, me nā lāʻau lapaʻau a me ka ʻepekema waiwai. nā lāʻau lapaʻau, hiki ke hoʻohana ʻia kēia pūhui i wahi hoʻomaka no ka hoʻomohala ʻana i nā lāʻau hou.ʻO ka loaʻa ʻana o kahi ʻano kumu benzimidazole i hui pū ʻia me nā hui ethoxy a me carboxylate e hāʻawi i nā manawa kūpono no ka hoʻololi hou ʻana i nā kemika e hoʻomaikaʻi i kāna mau waiwai pharmacological.Hiki i nā lāʻau lapaʻau ke ʻimi i ka pilina hana-hana (SAR) o kēia pūhui ma o ka hoʻohui ʻana i nā analogs me nā ʻano like ʻole o nā kaulahao ʻaoʻao a me nā pūʻulu hana.Hiki i kēia ke kōkua i ka ʻike ʻana i nā hoʻololi hoʻololi e hoʻomaikaʻi ai i ka ikaika o ka lāʻau, ke koho ʻana, a me nā waiwai pharmacokinetic. Hoʻonui pū ʻia ka hoʻohana ʻana o ka pūhui i ke kahua o ka ʻepekema waiwai.ʻO kāna ʻano kemika kūʻokoʻa a me nā hui hana e kūpono ia no ka hoʻohana ʻana ma ke ʻano he hale kūkulu hale i ka synthesis o nā mea hou.Hiki ke hoʻohana ʻia i ka hoʻomohala ʻana i nā polymers, nā uhi, a i ʻole nā ​​​​mea ʻē aʻe kahi i koʻikoʻi ai ka hoʻonohonoho pololei ʻana o nā ʻātoma a me ka loaʻa ʻana o nā pūʻulu hana kūikawā no nā waiwai kino a i ʻole kemika. 2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole] -7-Carboxylate hiki ke lawelawe ma ke ʻano he ʻimi molekala a mea hana paha ma nā wahi noiʻi like ʻole.Hiki i kāna mau pūʻulu hana pono ke kūpono no ka hoʻopaʻa inoa ʻana a i ʻole ke kau inoa ʻana i nā biomolecules kikoʻī no nā kumu hoʻokolohua.Hiki ke hoʻohana ʻia kēia pūhui i nā hoʻokolohua biological a i ʻole nā ​​ʻenehana kiʻi no ke aʻo ʻana i nā pilina molekala, nā pilina protein-protein, a i ʻole nā ​​​​kaʻina kelepona.E hoʻāʻo ʻia ka pūhui, me ka in vitro a me in vivo assays, e loiloi i kāna hana olaola, ʻona, a me nā waiwai pharmacological ʻē aʻe.Eia kekahi, e nānā pono ʻia kona palekana a me ka maikaʻi ma mua o ka noʻonoʻo ʻana i kona hoʻohana ʻana i nā hoʻonohonoho lāʻau lapaʻau. hoʻohiki i ka noiʻi lāʻau lapaʻau, ʻepekema waiwai, a me ka hoʻomohala ʻana i ka molecular probe.Hāʻawi kona ʻano kemika kūʻokoʻa i nā manawa no ka hoʻololi ʻana, e hiki ai i ka optimization o kāna waiwai pharmacological a i ʻole ka hoʻohana ʻana i ka synthesis o nā mea hou.Eia nō naʻe, koi ʻia ka noiʻi hou a me ka hoʻāʻo ʻana e ʻimi a hōʻoia i kāna mau noi i kēia mau kahua.