Nā huahana

ʻO N (ε) -trifluoroacetyl-L-lysine kahi hua kikoʻī o ka amino acid lysine, kahi i pale ʻia ai ka hui amino epsilon (ε) e kahi hui trifluoroacetyl (TFA).Loaʻa kēia pūhui i ka noi ma nā wahi like ʻole, ʻoi loa i ka peptide synthesis a me ka noiʻi biochemical. ʻO kahi hoʻohana nui o N (ε) -trifluoroacetyl-L-lysine i loko o ka solid-phase peptide synthesis (SPPS).He kuleana koʻikoʻi nā peptide i nā kaʻina hana olaola, a pono kā lākou synthesis i ka hui pū ʻana o nā waikawa amino.ʻO ka pūʻulu pale TFA ma ka hui epsilon amino o lysine e pale i nā hopena i makemake ʻole ʻia i ka wā o ka hoʻokumu ʻana i ka paʻa peptide ʻoiai e ʻae ana i nā waikawa amino ʻē aʻe e hui pū i nā kūlana i makemake ʻia.Ke hoʻopau ʻia ka hui peptide, hiki ke wehe ʻia ka hui pale TFA, a hiki ke hoʻolōʻihi ʻia ke koena N (ε) -trifluoroacetyl-L-lysine e hoʻohui i nā kaʻina peptide kikoʻī. N (ε) -trifluoroacetyl-L-lysine pū kekahi hoʻohana ʻia i ka noiʻi biochemical e aʻo i ke ʻano o ka protein, ka hana, a me nā pilina.Hiki iā ia ke hana ma ke ʻano he mea hana e noiʻi ai i ke kuleana o nā koena lysine i nā pilina protein-protein, nā pilina protein-DNA, a me nā hoʻololi ma hope o ka unuhi ʻana.Ma ka hoʻokomo ʻana i ka pūʻulu TFA, hiki ke hoʻololi ʻia nā waiwai kemika o ka lysine, e ʻae ai i ka noiʻi ʻana i nā kaʻina hana lysine-mediated i loko o nā ʻōnaehana biological. ʻōnaehana lawe lāʻau.Ma ka hoʻohui ʻana i nā mea lapaʻau kūikawā i ke koena lysine ma o ka hui TFA, hiki ke hoʻonui i ka paʻa a me ke koho ʻana o ka lāʻau lapaʻau, e alakaʻi ana i ka hoʻonui ʻana i ka pono a me ka hoʻemi ʻana i nā hopena ʻaoʻao.Ua ʻimi ʻia kēia hoʻolālā i ka hāʻawi ʻana i nā lāʻau anticancer, antibiotics, a me nā lāʻau lapaʻau ʻē aʻe. .ʻO kona ʻano kemika kū hoʻokahi a me ka hoʻoulu ʻana e lilo ia i mea hoʻomaka maikaʻi a i ʻole waena no ka synthesis o nā molekala organik paʻakikī, me nā lāʻau lapaʻau, agrochemical, a me nā mea waiwai. ma muli o ka mālama pono ʻana.Manaʻo ʻia e hana i loko o kahi keʻena hoʻoheheʻe maikaʻi a hoʻohana i nā lako pale pilikino kūpono, e like me nā mīkina lima a me nā goggles palekana. synthesis, noiʻi biochemical, hāʻawi lāʻau lapaʻau i manaʻo ʻia, a me ka synthesis organik.ʻO kona hiki ke pale i ka pūʻulu epsilon amino o lysine e hiki ai i ka peptide synthesis pololei, aʻo kāna mau mea kemika i hoʻololi ʻia e hiki ai ke aʻo ʻana i nā kaʻina hana lysine-mediated.Ke mālama pono ʻia, hōʻike ʻo N(ε)-trifluoroacetyl-L-lysine i mea hana pono i nā noi ʻepekema a me nā ʻoihana.