Nā huahana

ʻO Flucytosine, i ʻike ʻia ʻo 5-fluorocytosine a i ʻole 5-FC, he lāʻau antifungal synthetic i hoʻohana mua ʻia no ka mālama ʻana i nā maʻi fungal.Hoʻokaʻawale ʻia ʻo ia ma ke ʻano he antimetabolite, ʻo ia ka mea e hoʻopilikia ai i nā kaʻina metabolic maʻamau o nā cell fungal, e alakaʻi ana i kā lākou inhibition a make paha.Hoʻohana pinepine ʻia ʻo Flucytosine me nā lāʻau antifungal ʻē aʻe no ka maikaʻi loa.Hoʻohana pinepine ʻia i ka hui pū ʻana me kahi mea antifungal ʻē aʻe, e like me amphotericin B a i ʻole fluconazole, e hoʻonui i kāna hana antifungal.Hoʻohana ka Flucytosine ma ke komo ʻana i nā sela fungal a hoʻololi i ka 5-fluorouracil, kahi antimetabolite cytotoxic.Hoʻopilikia ka 5-fluorouracil i ka synthesis o ka fungal RNA a me DNA, no laila ke kāohi nei i ka ulu a me ka hana hou.ʻO kēia ʻano hana synergistic e kōkua i ka hakakā ʻana i kahi ākea ākea o nā pathogens fungal a hoʻonui i ka pono o ka mālama ʻana.Manaʻo ʻia ʻo Flucytosine kekahi o nā lāʻau lapaʻau mua i hui pū ʻia me amphotericin B no ka mālama ʻana i kēia maʻi.ʻO ka hui pū ʻana e kōkua i ka lanakila ʻana i nā palena o kēlā me kēia lāʻau lapaʻau wale nō a loaʻa i nā helu hoʻōla kiʻekiʻe.Loaʻa ka Flucytosine i nā pae kūpono i loko o ka wai cerebrospinal, e ʻae iā ia e hoʻopaʻa pono i ka maʻi fungal i loko o ke kikowaena o ke kikowaena.Eia nō naʻe, hiki ke kaupalena ʻia ka hoʻohana ʻana ma muli o ka pilikia o ka hoʻomohala ʻana i ke kū'ē, no ka mea, hiki i ka haʻiki ke loaʻa nā hoʻololi e hoʻemi ʻole ai i ka lāʻau.Pono ka nānā pono a me ka loiloi manawa o ka pane therapeutic i ka wā e hoʻohana ai i ka flucytosine e hōʻoia i nā hopena lapaʻau kūpono.ʻO nā hopena ʻaoʻao maʻamau ka pilikia o ka ʻōpū, e like me ka nausea, ka luaʻi, a me ka maʻi maʻi.Hiki iā ia ke hoʻopau i ka iwi iwi, kahi e hoʻemi ai i ka hana ʻana o nā pūnaʻi koko.Hoʻomaʻamaʻa pinepine ʻia nā hoʻāʻo koko maʻamau no ka nānā ʻana i ka helu o ke koko i ka wā o ka mālama ʻana.Hana ia ma ka hoʻopili ʻana i ka synthesis nucleic acid fungal, kaohi ʻana i ko lākou ulu ʻana a me ka hana hou ʻana.Hoʻohana maʻamau ka Flucytosine i ka hui pū ʻana me nā lāʻau antifungal ʻē aʻe a he mea koʻikoʻi loa ia i ka mālama ʻana o Cryptococcus neoformans maningitis.Eia nō naʻe, pono ka nānā pono ʻana o kāna hoʻohana ʻana ma muli o ka pilikia o ke kū'ē a me nā hopena ʻino.