Ka waiʻuma Folic: 59-30-3 99%
| Helu Helu | XD90435 |
| inoa mea kūʻai | Folic Acid |
| CAS | 59-30-3 |
| ʻĀpana Molekala | C19H19N7O6 |
| Kaumaha Molecular | 441.40 |
| Nā kikoʻī mālama | Ambient |
| Kānāwai Kūʻai Kūlike | 29362900 |
Huahana Huahana
| Ka nana aku | Melemele a ʻalani ka pauka crystalline |
| Hoʻāʻo | 99% |
| Wai | 5.0 - 8.5% |
| Maʻemaʻe Chromatographic | <2.0% |
| Ka hikiwawe | ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai a me ka hapa nui o nā mea hoʻoheheʻe organik.E hoʻoheheʻe ʻia i loko o nā ʻakika dilute a me nā hopena alkaline |
| Koena ma ka Ignition | <0.3% |
I loko o kēia haʻawina, ʻo ka poly(ethylene oxide) -b-poly (propylene oxide) -b-poly (ethylene oxide) -ploy (N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer i hoʻohana ʻia i ka thermosensitive a me ka folate. synthesized.Ua hōʻoia ʻia ke ʻano a me ke kaumaha molekala o ka copolymer e 1H NMR, FT-IR a me GPC.ʻO ka wela haʻahaʻa haʻahaʻa haʻahaʻa (LCST) o ka copolymer he 39.8 degere C. Ma ka hoʻohana ʻana i ka doxorubicin (DOX) ma ke ʻano he lāʻau hoʻohālike, ua hoʻokumu hou ʻia nā micelles i hoʻopaʻa ʻia i DOX i hoʻopaʻa ʻia i ka folate ma luna o ka copolymer.Ua hōʻike ʻia nā micelles blank a me DOX i nā ʻano spherical a ʻo ko lākou awelika anawaena he 35 nm a me 50 nm.ʻO nā ʻano hoʻokuʻu in vitro o nā micelles i hoʻouka ʻia i DOX ua pili i ka mahana a ʻoi aku ka wikiwiki o ka hoʻokuʻu ʻana o DOX ma 42 degere C (ma luna o LCST) ma mua o 37 degere C (ma lalo o LCST).Eia kekahi, ua hōʻike ʻia ka cytotoxicity o nā micelles manuahi DOX a me DOX i hoʻouka ʻia ma nā laina cell cancer cervical cancer HeLa a me nā laina cell cancer A549 i hōʻike ʻia ua hoʻonui ka folate i ka lawe ʻana o nā micelles i loko o nā pūnaewele i hoʻopaʻa ʻia i hōʻike nui ʻia i nā folate receptors.
