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ʻO Islet amyloid polypeptide (IAPP; ʻike ʻia ʻo amylin) ke kuleana no ka hoʻokumu ʻana o ka islet amyloid i ka maʻi maʻi type 2, a ua manaʻo ʻia ka mea ʻawaʻawa i hoʻokomo ʻia e IAPP i ka nalo ʻana o ka β-cell mass e pili ana i nā pae hope o ka maʻi diabetes type 2.Hiki i ke kūkulu ʻana o Islet amyloid ke hana i ka hana ʻole ʻana ma hope o ka hoʻololi ʻana.Hana ʻia ʻo IAPP ma ke ʻano he prohormone, pro-islet amyloid polypeptide (proIAPP), a hana ʻia i loko o nā granules huna o nā pancreatic β-cells.Loaʻa nā ʻano proIAPP i hana ʻia i loko o nā waihona amyloid;ʻO ka mea kaulana loa he 48 koena waena, proIAPP (1-48), e komo pū ana me ka N-terminal pro-extension, akā ua hoʻoponopono pono ʻia ma ka C-terminus.Hiki ke hana i ka hana ʻole i ka hana ʻana i ka amyloid islet ma o ka hoʻolaha ʻana i nā pilina me nā proteoglycans sulfated o ka matrix extracellular, ʻo ia hoʻi, e hoʻoikaika i ka hoʻokumu ʻana o amyloid.Hōʻike mākou i ka fuchsin acid (3-(1-(4-amino-3-methyl-5-sulphonatophenyl)-1-(4-amino-3-sulphonatophenyl)methylene)cyclohexa-1,4-dienesulphonic acid), he mea maʻalahi. ʻO ka sulfonated triphenyl methyl derivative, he mea hoʻopaneʻe ikaika o ka hana amyloid e ka proIAPP(1-48) waena.ʻOi aku ka paʻakikī o ka triphenyl methane derivative wikiwiki ʻōmaʻomaʻo FCF {ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa -2,5-dienylidene]-[(3-sulfophenyl)methyl]azanium} hoʻopaʻa pū i ka hoʻokumu ʻana o amyloid e IAPP a me ka proIAPP hoʻoponopono waena.Kāohi nā pūhui ʻelua i ka hoʻokumu ʻana o ka amyloid e nā hui ʻana o ka proIAPP waena a me ke kumu hoʻohālike glycosaminoglycan heparan sulfate.Kāohi pū ka acid fuchsin i ka hoʻokumu ʻana o ka amyloid glycosaminoglycan-mediated e ka IAPP makua.ʻO ka hiki ke kāohi i ka hoʻokumu ʻana o ka amyloid ʻaʻole ia ma muli o ka sulfonated pūhui, no ka mea, ʻo ka sulfonated inhibitor o amyloid-β, tramiprosate, ʻaʻole ia he mea hoʻopale o ka hoʻokumu amyloid e proIAPP(1-48).