Furazolidone Cas: 67-45-8
Helu Helu | XD91885 |
inoa mea kūʻai | ʻO ka furazolidone |
CAS | 67-45-8 |
ʻAno Molekalala | C8H7N3O5 |
Kaumaha Molecular | 225.16 |
Nā kikoʻī mālama | Ambient |
Kānāwai Kūʻai Kūlike | 29349990 |
Huahana Huahana
Ka nana aku | Pauda melemele |
ʻO Assay | 99% min |
Lae hehee | 254-256°C (Dek.) |
Lae paila | 366.66°C (manaʻo koʻikoʻi) |
mānoanoa | 1.5406 (manaʻo koʻikoʻi) |
hōʻike hoʻopaʻapaʻa | 1.7180 (manaʻo) |
Fp | 2 °C |
hikiwawe | ʻakika formic: hiki ke hoʻoheheʻe ʻia 50mg/mL |
pka | -1.98±0.20(Wanamua) |
Pilikino | Māmā Māmā |
λmax | 365nm(DMSO)(kukui.) |
Paʻa | Paʻa.Hiki ke puhi.ʻAʻole kūpono me nā mea oxidizing ikaika. |
Ua like ke ano o ka antibacterial spectrum o furazolidone me ka furazolidone.Ma ke ʻano he lāʻau anti-infection, ʻoi aku ka maikaʻi o ka mālama ʻana iā Salmonella, Shigella, Escherichia coli, Proteus, Streptococcus, a me Staphylococcus aureus.ʻAʻole maʻalahi ka bacteria e hoʻomohala i ka lāʻau kūʻē i kēia lāʻau.ʻAʻole nō hoʻi he kūʻē kūʻē me nā lāʻau lapaʻau sulfa class.Hoʻohana nui ʻia no ka mālama ʻana i ka maʻi maʻi, enteritis, typhoid, paratyphoid a me ka mālama ʻana o ka trichomoniasis vaginal.
2. ʻO ka huahana he fungicide nona kahi ākea antibacterial spectrum.Ma ke ʻano he lāʻau anti-infective, kūpono ia no ka mālama ʻana i nā ʻano bacteria Gram-positive a maikaʻi ʻole e like me Escherichia coli, Bacillus anthracis, a me Paratyphoid bacilli.ʻAʻole maikaʻi wale ia i ka mālama ʻana i ka dysentery, enteritis, akā hoʻohana ʻia no ka mālama ʻana i nā maʻi maʻi.I kēia mau makahiki i hala iho nei, he hana maikaʻi kēia no ka mālama ʻana i ka maʻi typhoid.Ma ke ʻano he mea hoʻohui no nā lāʻau lapaʻau holoholona a me nā mea inu, loaʻa iā ia ka hopena antibacterial kūʻokoʻa ma Salmonella, Escherichia coli a me Salmonella pullorum a loaʻa kekahi hopena inhibitory i ka protozoa (coccidia bacteria, a me nā mea ʻē aʻe.)Ua hoʻohana ʻia kahi mea liʻiliʻi o ka furazolidone no nā noi ʻē aʻe (e like me ka pena wai-soluble a me ka pulp pepa) ma ke ʻano he fungicides.
3. He lāʻau anti-infective i hoʻohana ʻia no ka pale ʻana i ka maʻi o ka ʻōpū.
4. ʻO Furazolidone, ma ke ʻano he fungicide, he ākea ākea antibacterial spectrum.ʻO nā maʻi maʻi maʻi loa ʻo Escherichia coli, Bacillus anthracis, paratyphoid rod, Shigella, a me Klebsiella pneumoniae.Pilikia ʻo Salmonella typhi iā ia.Hoʻohana nui ʻia ia no ka mālama ʻana i nā maʻi maʻi-i hoʻoulu ʻia i ka dysentery, enteritis, a me kolera.Hiki ke hoʻohana ʻia no ka mālama ʻana i ka typhoid, paratyphoid, giardiasis, a me trichomoniasis.Hiki ke hoʻohana ʻia ka hui pū ʻana me nā lāʻau anti-acid no ka mālama ʻana iā Helicobacter pylori-induced gastric inflammation.Nā waiwai: ka pauda melemele a i ʻole ka pauka crystalline, ʻaʻala ʻole, ʻaʻohe ʻono mua a laila lilo i ʻawaʻawa iki;hikiwawe loa i ka wai a me ka ethanol;hiki ke hoʻoheheʻe ʻia i loko o ka chloroform a hiki ʻole ke hoʻoheheʻe ʻia i ka etera, hiki ke hoʻoheheʻe ʻia i ka dimethylformamide a me ka nitromethane.Mp: 255 a 259 °C.Decompose i ka wā e hemo ai.
Hoʻohana ʻia ʻo Furazolidone i nā maʻi gastrointestinal a me ka vaginitis.Hoʻohana nui ʻia ia i nā ʻāina ulu e mālama i nā maʻi diarrheal o nā etiology like ʻole, akā ʻaʻole ia ka lāʻau i koho ʻia inā ʻike ʻia kahi pathogen kikoʻī.Hoʻohana ʻia ma ke ʻano he lālani lua i ka giardiasis a ma ke ʻano he ʻāpana o nā regimens multidrug i ka maʻi Helicobacter i kākoʻo ʻia.
3-[(5-Nitrofurylidene)amino]-2-oxazolidinone (Furoxone) e like me ka pauka crystalline melemele me ka ʻona ʻawaʻawa.Loaʻa i ka Furazolidone ka hana bactericidal e kūʻē i kahi ākea ākea o nā ʻōpū o ka ʻōpū, me S. aureus, E. coli, Salmonella, Shigella, Proteus spp., Enterobacter, a me Vibrio cholerae.Manaʻo ʻia ia no ka mālama waha o ka maʻi bacterial a i ʻole protozoaldiarrhea i hoʻokumu ʻia e nā mea maʻi.ʻO ka dosage maʻamau he 100 mg 4 mau manawa i kēlā me kēia lā.
ʻO kahi hapa liʻiliʻi wale nō o ka furazolidoneis i hāʻawi ʻia ma ka waha.Ma kahi o 5% o ka nui o ka waha i ʻike ʻia ma ka mimi ma ke ʻano o nā metabolites.