Nā huahana

ʻO RasGrf1 a me RasGrf2 nā mea homologous mammalian guanine nucleotide exchange e hiki ai ke hoʻoikaika i nā Ras a i ʻole Rho GTPases.Hōʻike maikaʻi ʻia nā genes RasGrf i loko o ka ʻōnaehana nūnū waena, ʻoiai ʻo ka hōʻike kikoʻī o kēlā me kēia locus e hiki mai ana ma kahi ʻē aʻe.ʻO RasGrf1 kahi moʻo i hōʻike ʻia e ka makua, i hōʻike ʻia ma hope o ka hānau ʻana.Ma ka hoʻohālikelike, ʻaʻole paʻi ʻia ʻo RasGrf2 a hōʻike i kahi ʻano hōʻike ākea.Hiki ke ʻike ʻia nā ʻano isoforms no nā genes ʻelua ma nā ʻano kelepona like ʻole.Hōʻike nā protein RasGrf i nā hale modular i haku ʻia e nā kikowaena he nui me nā kumu CDC25H a me DHPH kuleana no ka hoʻolaha ʻana i ka hoʻololi GDP/GTP, ma kēlā me kēia, ma nā pahu Ras a Rho GTPase.Pono nā kikowaena like ʻole e wehewehe i kā lākou hana hoʻololi intrinsic a e hoʻololi i ka kikoʻī o kā lākou hana hana i mea e hoʻopili ai i nā hōʻailona upstream like ʻole i nā pahuhopu i lalo a me nā pane kelepona.ʻOiai kā lākou homology, hōʻike ʻo RasGrf1 a me RasGrf2 i nā kikoʻī kikoʻī like ʻole a me nā kuleana hana ʻole i nā ʻano hōʻailona like ʻole e pili ana i ka ulu ʻana o ka cell a me ka ʻokoʻa a me ka neuronal excitability a me ka pane a i ʻole synaptic plasticity.ʻOiai hiki ke hoʻoulu ʻia nā RasGrfs ʻelua e nā glutamate receptors, G-protein-coupled receptors a i ʻole nā ​​hoʻololi ʻana i ka neʻe ʻana o ka calcium intracellular, ʻo RasGrf1 wale nō ka mea i hōʻike ʻia e LPA, cAMP, a i ʻole agonist-activated Trk a me cannabinoid receptors.ʻO ka nānā ʻana i nā ʻano ʻiole knockout i wehe i kahi haʻawina kikoʻī o RasGrf1 i nā kaʻina o ka hoʻomanaʻo a me ke aʻo ʻana, photoreception, ka mālama ʻana i ka ulu ʻana o ka post-natal a me ka nui o ke kino a me ka hana pancreatic β-cell a me ka homeostasis glucose.No RasGrf2, ua wehewehe ʻia nā kuleana kikoʻī i ka hoʻonui ʻana o ka lymphocyte, nā pane hōʻailona T-cell a me lymphomagenesis.