Nā huahana

Hoʻohana nui ʻia kekahi mau mea like guanosine, ʻo ia hoʻi acyclovir (a me kāna valaciclovir prodrug oral), penciclovir (ma kāna ʻano prodrug oral, famciclovir) a me ganciclovir, no ka mālama ʻana i ka herpesvirus [ie herpes simplex virus type 1 (HSV-1), a me ke ʻano. 2 (HSV-2), ma'i ma'i varicella-zoster (VZV) a/a i 'ole kanaka cytomegalovirus (HCMV)].I nā makahiki i hala iho nei, ua hoʻomohala ʻia kekahi mau analogues guanosine hou, me ka 3-membered cyclopropylmethyl a me -methenyl derivatives (A-5021 a me synguanol) a me ka 6-membered D- a me L-cyclohexenyl derivatives.Ua hoʻoholo ʻia ka hana o ka acyclic/carbocyclic guanosine analogues e kūʻē i kahi ākea ākea o nā maʻi, me ka HSV-1, HSV-2, VZV, HCMV, a me nā herpesviruses kanaka type 6 (HHV-6), ʻano 7 (HHV- 7) a me ke ʻano 8 (HHV-8), a me ka maʻi hepa B (HBV).ʻO nā analogues guanosine hou (ʻo ia hoʻi, A-5021 a me D- a me L-cyclohexenyl G) ua ʻike ʻia he ikaika loa i kēlā mau maʻi (HSV-1, HSV-2, VZV) e hoʻopili ai no kahi thymidine kinase (TK) kikoʻī. ʻo kā lākou hana antiviral (ma kahi hapa liʻiliʻi) e pili ana i ka phosphorylation e ka TK i hoʻokomo ʻia.Ua ʻike pū ʻia ka hana antiviral i hōʻailona ʻia me A-5021 kūʻē iā HHV-6 a me D- a me L-cyclohexenyl G kūʻē iā HCMV a me HBV.Hiki ke hoʻoikaika nui ʻia ka hana antiviral o ka acyclic/carbocyclic nucleoside analogues e ka mycophenolic acid, kahi mea hoʻopale ikaika o ka inosine 5'-monophosphate (IMP) dehydrogenase.ʻO nā analogues carbocyclic guanosine hou (ʻo ia hoʻi A-5021 a me D- a me L-cyclohexenyl G) paʻa i ka ʻōlelo hoʻohiki nui, ʻaʻole wale ma ke ʻano he antiviral agents no ka mālama ʻana i nā maʻi herpesvirus, akā he mau mea antitumor pū kekahi no ka hui pū ʻana o ka gene therapy / chemotherapy o ka maʻi kanesa, inā ua hoʻololi ʻia (kahi hapa o) nā pūnaewele maʻi e ke ʻano TK viral (HSV-1, VZV).