Nā huahana

ʻO Ivermectin (Cardomec, Eqvalan, Ivomec) kahi hui o 22,23-dihydro derivatives o avermectins B1a a me B1b i hoʻomākaukau ʻia e ka hydrogenation catalytic.He mau lālā ʻo Avermectins o ka ʻohana o nā lāʻau lapaʻau paʻakikī paʻakikī i hana ʻia e ka fermentation me kahi ʻano o Streptomycesavermitilis.ʻO kā lākou ʻike ʻia ma muli o ka nānā ʻana i nā moʻomeheu no nā mea anthelmintic mai nā kumu kūlohelohe.Hoʻoikaika ʻo Ivermectin i ka haʻahaʻa haʻahaʻa e kūʻē i nā ʻano nematodes a me nā arthropods i parasitize holoholona.
Ua hoʻokō ʻo Ivermectin i ka hoʻohana ākea i ka hoʻomaʻamaʻa holoholona ma ʻAmelika Hui Pū ʻIa a me nā ʻāina he nui a puni ka honua no ka mālama ʻana i nā endoparasites a me nā ectoparasite ma nā holoholona home.Ua ʻike ʻia ka maikaʻi no ka mālama ʻana i ka onchocerciasis ("makapō muliwai") i loko o nā kānaka, kahi maʻi koʻikoʻi i hana ʻia e ka roundwormOncocerca volvulus, laha ma West a me Central Africa, ka Middle East, a me ʻAmelika Hema a me Central America. nā ʻano o ka nematode, ka mea e hana ai i ka ʻili a me nā nodule ʻiʻo i ʻano o ka maʻi a hiki ke alakaʻi i ka makapō.Hōʻike nā haʻawina e pili ana i ka hana o ka ivermectin e poloka ia i ka hoʻoili ʻana o ka interneuron-motor neuron i nā nematodes ma o ka hoʻoulu ʻana i ka hoʻokuʻu ʻana o ka neurotransmitter inhibitory GABA.

Loaʻa i ka Ivermectin ka hana ākea ākea e hiki ai ke hoʻopilikia i nā nematodes, nā iniseti, a me nā maʻi acarine.ʻO ia ka lāʻau i koho ʻia i ka onchocerciasis a he mea maikaʻi loa ia i ka mālama ʻana i nā ʻano ʻano filariasis, strongyloidiasis, ascariasis, loiasis, a me nā larva migrans cutaneous.He ʻeleu nō hoʻi ia e kūʻē i nā mites like ʻole.ʻO ia ka lāʻau lapaʻau i koho ʻia no ka mālama ʻana i nā kānaka i loaʻa i ka Onchocerca volvulus, e hana ana ma ke ʻano he lāʻau microfilaricidal e kūʻē i ka ʻili e noho ana i ka ʻili (microfilaria).Hiki i ka lapaau makahiki ke pale i ka makapo mai ka ocular onchocerciasis.ʻOi aku ka maikaʻi o ka Ivermectin ma mua o ka diethylcarbamazine i ka filariasis bancroftian, a hoʻemi ia i ka microfilaremia a kokoke i nā pae ʻole.I ka brugian filariasis diethylcarbamazine-induced clearance hiki ke oi aku.Hoʻohana ʻia ia e mālama i nā larva migrans a me ka hoʻolaha ʻana i ka strongyloidiasis.ʻAʻole i hoʻokumu pono ʻia kāna hoʻohana palekana i ka wā hāpai.