L-Histidine Cas: 71-00-1 98.5% Keʻokeʻo keʻokeʻo a i ʻole ka pauka crystalline
| Helu Helu | XD90301 |
| inoa mea kūʻai | L-Histidine |
| CAS | 71-00-1 |
| ʻĀpana Molekala | C6H9N3O2 |
| Kaumaha Molecular | 155.15 |
| Nā kikoʻī mālama | Ambient |
| Kānāwai Kūʻai Kūlike | 29332990 |
Huahana Huahana
| Hoʻāʻo | 98.5% min |
| Ka nana aku | ʻO nā kristal keʻokeʻo a i ʻole ka pauka crystalline |
| Papa | USP39 |
| Kahuli kiko'ī | +12.6 ° a i +14.0 ° |
| ʻIkepili | Hoʻopili ʻana i ka infrared |
| pH | 7.0 - 8.5 |
| SO4 | <=0.03% |
| Fe | <=30ppm |
| Nalo ma ka maloo | <=0.2% |
| Koena ma ka Ignition | <=0.1% |
| Cl | <=0.05% |
| Nā metala kaumaha (PB) | <=15ppm |
| Nā hui pili | ʻAʻole i ʻoi aku ma mua o 0.5% o kēlā me kēia haumia;ʻAʻole ʻoi aku ma mua o 2.0% o ka nui o nā haumia i loaʻa |
ʻO ka quadruplex e hoʻokumu ana i nā kaʻina waiwai G i puʻunaue like ʻole i loko o ka genome kanaka.ʻO kā lākou hoʻonui ʻana i nā mea hoʻolaha oncogenic a me nā telomeres ua hoʻoulu i ka hoihoi i ka huli ʻana iā G-quadruplex (GQ) no kahi lāʻau anticancer.Ma ʻaneʻi, hōʻike mākou i kahi loiloi quantitative e pili ana i ka conformations a me ka dynamics o GQ e hoʻokumu ana i nā kaʻina i ana ʻia e ka fluorescence molekula hoʻokahi.Hoʻohui hou, pili mākou i kēia mau waiwai i nā ligands targeting GQ a me G4 resolvase 1 (G4R1) protein binding.Hōʻike kā mākou hopena i ka lōʻihi o ka loop (nā ʻāpana ʻole G) a me ke kaʻina i ka conformation o ka GQ.Hōʻike ʻia nā ʻano mole mole i ka manawa maoli e pili pū ana ka dynamics pelu i ka haku mele.Hōʻike mākou i nā molekole liʻiliʻi e hoʻopaʻa i ka GQ, N-methyl mesoporphyrin IX (NMM), kāna analog, NMP a me ka protein G4R1 e hoʻopaʻa koho i ka conformation GQ like.Hōʻike kā mākou ʻike i ka paʻakikī o ka hoʻopili ʻana o GQ i hoʻokele ʻia e ka lōʻihi o ka loop a me ke kaʻina a pehea e hoʻoholo ai ka conformation GQ i ka mole liʻiliʻi a me ka propensity paʻa pūmua.
