nūhou

ʻO ka neocuproine reagent he mea hoʻonā no ka hoʻoholo keleawe, keʻokeʻo a melemele-ʻeleʻele paha, hoʻonāukiuki.Hoʻohana nui ʻia e like me ka reagent no ka hoʻoholo ʻana i ka cuprous, photometric determination o ke keleawe, ka hoʻoholo ʻana o ke kō koko koko ultra-micro;hoʻohana ʻia ʻo Neocuproine hydrochloride monohydrate i ke ana ʻana i ka hoʻoheheʻe keleawe ma nā ʻāpana Cu-Ni me ka hoʻohana ʻana i ke ʻano colorimetric.Ua hoʻohana ʻia nō hoʻi i ka hoʻomākaukau ʻana i ka ʻenehana paʻakikī i ke aʻo ʻana i ka mana antioxidant assays i loko o nā laʻana olaola e pili ana i nā paʻakikī hoʻemi Cu.Hiki ke hoʻohana ʻia ma ke ʻano he precursor no ka hoʻomākaukau ʻana i ka neocuproine, hoʻohana ʻia ma ke ʻano he reagent analytical no ka hoʻoholo ʻana i ke keleawe i nā laʻana kaiapuni me ka hoʻohana ʻana i ka ʻenehana spectrophotometric.

Eia naʻe, ʻokoʻa loa ka hoʻohana ʻana o ia lāʻau lapaʻau i ka lāʻau lapaʻau. I kēia manawa, ua ʻae ʻia ʻo Eribulin no ke kūʻai ʻana e ka National Medical Products Administration (NMPA) o koʻu ʻāina no ka mālama ʻana i nā maʻi maʻi maʻi maʻi maʻi maʻi maʻi a i ʻole metastatic i loaʻa ma ka liʻiliʻi ʻelua. nā regimens (me nā anthracyclines a me nā ʻauhau) i ka wā i hala.Ua lawe mai i kahi ʻano lāʻau lapaʻau hou i ke kahua o ka maʻi maʻi maʻi maʻi maʻi ma Kina, lawe pū ʻo ia i nā koho lapaʻau hou aku no nā maʻi.
ʻO Eribulin kahi mea hoʻopiʻi non-taxane tubulin.ʻAʻole like me ka taxane a me ka vinblastine tubulin inhibitors, Eribulin kahi hana kūikawā o ka hana, e hana ai ʻo Eribulin He mea maikaʻi loa ia i nā maʻi ma hope o ke kūʻē ʻana i ka lāʻau i ka yew;Loaʻa iā Eribulin nā hopena non-cytotoxic, me ka hoʻoponopono hou ʻana i ka vascular, hoʻonui i ka perfusion o nā lāʻau ʻē aʻe i ka microenvironment tumor, synergizing nā lāʻau lapaʻau ʻē aʻe, a me ka hoʻohuli ʻana i nā cell tumor ʻO ka epidermal-mesenchymal transition a pēlā aku.

Mai ka huina nui o halichondrin B, ka hoʻohana ʻana i nā reagents keleawe hou ma ke ʻano he waena, i ka hoʻololi ʻana o Eribulin, i ka hana ʻenehana o Eribulin, ua hoʻohana nā ʻepekema mai nā ʻoihana aʻoaʻo a me nā lāʻau lapaʻau ma mua o 20 mau makahiki o ka ʻimi.ʻO nā huahana kūlohelohe i loaʻa mai i ke kai ua lilo i lāʻau lapaʻau e hiki ke mālama i ka maʻi kanesa.ʻO ka noiʻi a me ka hoʻomohala ʻana o Eribulin no ka mea he mea nui ka reagent keleawe hou ma ke ʻano he kikowaena nui o kāna API.He kuleana nui ko ka copper reagent hou ma ke ʻano he pharmaceutical intermediate a me ka reagent no ka hoʻomaʻemaʻe ʻana i nā mea hana kiʻekiʻe.

ʻO ka molecular structure o Eribulin he 19 mau kikowaena chiral, a ʻo nā ʻanuʻu synthesis e like me 62 mau ʻanuʻu.A hiki i kēia manawa, ʻike ʻia ʻo Eribulin e ka ʻoihana ʻo ia ka lāʻau non-peptide paʻakikī loa i hana ʻia e ka synthesis chemical maʻemaʻe, a hiki ke kapa ʻia ʻo Mount Everest i ka ʻoihana synthesis chemical.
Hōʻike ka papa inoa kūleʻa o Eribulin i nā kiʻekiʻe kiʻekiʻe e hiki ai i nā hui lāʻau lapaʻau ke hoʻokō i ka synthesis kemika a me ka hana ʻoihana.Hāʻawi pū ia i nā manaʻo maʻi a me nā manaʻo lapaʻau a me nā koho i nā kauka Kina.Manaʻolana ʻia i ka hana lapaʻau e hiki mai ana, hiki i ka lāʻau chemotherapeutic hou ʻo Eribulin ke lawe mai i ka manaʻolana hou i nā maʻi maʻi maʻi umauma.