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Hoʻohana pinepine ʻia ʻo Dithiothreitol (DTT), CAS: 3483-12-3, ma ke ʻano he reagent noiʻi ʻepekema nui, ma ke ʻano he mea hoʻohaʻahaʻa no ka sulfhydryl DNA, kahi mea pale, a me ka hōʻemi ʻana i nā paʻa disulfide i nā protein.He hana koʻikoʻi ke ʻano hou o ka hoʻohui ʻōmaʻomaʻo i ka hoʻomaikaʻi ʻana i ka hana pākaukau.
ʻO ka Dithiothreitol (DTT) he mea hoʻohaʻahaʻa ikaika, a ʻo ka hiki ke hoʻohaʻahaʻa ʻia ma muli o ke kūpaʻa conformational o ke apo ʻeono lālā (loaʻa nā paʻa disulfide) i kona kūlana oxidation.ʻO ka hōʻemi ʻana o kahi paʻa disulfide maʻamau e ka dithiothreitol he ʻelua mau hopena hoʻololi pili sulfhydryl-disulfide.ʻO ka mana hoʻohaʻahaʻa o dithiothreitol (DTT) e pili ana i ka pH waiwai, a hiki ke pāʻani wale i ka hopena hoʻohaʻahaʻa i ka wā i ʻoi aku ka nui o ka pH ma mua o 7. ʻO kēia no ka mea ʻo nā anion deprotonated thiolate wale nō ka reactive, ʻoiai ʻaʻole nā ​​mercaptans, a me ka ʻO ka pKa o nā hui mercapto he 8.3.
Hoʻohana maʻamau ʻia ʻo Dithiothreitol (DTT) e hōʻemi i nā paʻa disulfide o nā molekole protein a me nā polypeptides.Hoʻohana maʻamau ia ma ke ʻano he mea pale pale sulfhydryl protein a hoʻohana ʻia i ka hoʻomākaukau ʻana i ka lāʻau lapaʻau e pale i nā koena cysteine ​​​​protein mai ka hana ʻana i nā disulfides intramolecular a me intermolecular.kī.Ma ke kaʻina o ka ʻike wai nucleic, hiki i ka dithiothreitol (DTT) ke hoʻopau i nā paʻa disulfide i loko o ka protein RNase, denature i ka RNase, a hoʻomaʻamaʻa i ka hana o nā hoʻokolohua e like me ka hale waihona puke RNA a me ka hoʻonui ʻana i ka RNA.Hoʻohana ʻia ʻo Dithiothreitol (DTT) ma ke ʻano he antidote no ka pale ʻana i nā cell a me nā ʻiʻo, ma ke ʻano he radioprotectant, etc.
Eia nō naʻe, ʻaʻole hiki i ka dithiothreitol (DTT) ke hoʻemi pinepine i nā paʻa disulfide i hoʻokomo ʻia i loko o ka hoʻolālā protein (ʻaʻole hiki ke komo i ka solvent).ʻO ka hōʻemi ʻana o ia mau paʻa disulfide e koi pinepine i ka denaturation o ka protein ma mua.
I mea e pale ai i ka hopena shuttle o nā pākahi lithium-sulfur a hoʻomaikaʻi i ka hana electrochemical o nā pākahi lithium-sulfur, e hoʻāʻo e hoʻohana i ka dithiothreitol (DTT) ma ke ʻano he mea ʻoki ʻoki e ʻoki i nā polysulfides kiʻekiʻe e pale aku iā lākou mai ka hemo ʻana.Hoʻohui ʻia ʻo Threitol (DTT) i loko o ka pepa kalapona nanotubes (MWCNTs) i hoʻomākaukau ʻia i kahi DTT interlayer.Hoʻokomo ʻia ka DTT interlayer ma waena o ka pepa electrode maikaʻi a me ka mea hoʻokaʻawale o ke pihi lithium-sulfur i ka hapalua-cell, a me ka sulfur-haʻi ʻili ākea o ka pepa electrode maikaʻi Ma kahi o 2mg/cm2.Hōʻoia nā hualoaʻa nānā SEM i ka hoʻopuehu ʻia ʻana o DTT ma ka ʻili a me nā hakahaka o ka pepa MWCNTs.Hōʻike nā hopena hoʻāʻo electrochemical i ka pākaukau lithium-sulfur me DTT sandwich structure i hoʻokuʻu mua ʻia ka mana kikoʻī o 1288 mAh/g ma ka helu o 0.05C.No ka manawa mua, ua kokoke ka coulombic i ka 100%, a ʻo ka mana kikoʻī i ka wā o ka hoʻouka ʻana a me ka hoʻokuʻu ʻana ma 0.5C, 2C, a me 4C hiki i ka 650mAh/g, 600mAh/g, a me 410mAh/g.Hiki i ka hoʻokomo ʻana i ka hana sandwich DTT ke ʻohi pono i nā polysulfides kiʻekiʻe.Ke pale nei ia mai ka neʻe ʻana i ka lithium negative electrode, no laila ke keʻakeʻa nei i ka hopena shuttle a hoʻomaikaʻi i ka paʻa o ka pōʻai a me ka coulomb pono o nā pā lithium-sulfur.
Pono e ʻike ʻia he mea ʻawaʻawa ka dithiothreitol (DTT).No ka laʻana, ma ke alo o nā metala hoʻololi, hiki i ka dithiothreitol (DTT) ke hana i ka pōʻino oxidative i nā molekala olaola.Ma ka manawa like, hiki i ka dithiothreitol (DTT) ) ke hoʻonui i ka ʻawaʻawa o kekahi mau pūhui i loaʻa i ka arsenic a me ka mercury.He ʻala ʻala ʻo Dithiothreitol (DTT), hiki ke hōʻino i ke olakino ma muli o ka inhalation a me ka pili ʻana i ka ʻili.No laila, pono ia e pale i ka wā o ka hana, e ʻaʻahu i nā masks, nā mīkina lima a me nā goggles, a e hana i loko o kahi pahu hau.

ʻO Thithreitol (DTT) ma ke ʻano he shearing agent i nā ʻeke lithium-sulfur
Manaʻo ʻia ʻo Lithium-sulfur pākaukau he ʻōnaehana pākaukau me ka mana nui ma muli o kona kiʻekiʻe o ka ikehu kiʻekiʻe a me ka pale ʻana i ke kaiapuni.Eia nō naʻe, ʻo ka "hopena kaʻa" o nā polysulfides e alakaʻi i ke ola pōʻai maikaʻi ʻole a me ka hoʻokuʻu ʻana iā ia iho, kahi e kaupalena ai i kāna noi.kumu.
Hiki ke hoʻohui ʻia ʻo Thiothreitol (DTT) i ka pākaukau ma ke ʻano he ʻāhi ʻoki.Hiki iā ia ke ʻoki wikiwiki i nā mea paʻa disulfide i ka lumi wela, e ʻoki i nā polysulfides kiʻekiʻe e pale ai i kā lākou hoʻoheheʻe ʻana, e kāohi i ka hopena shuttle, a hoʻonui i ka lithium ʻO ka hana electrochemical o nā pā sulfur.
ʻO Dithiothreitol (DTT) ma ke ʻano he mea hoʻohui electrolyte i loko o nā ʻeke alumini alkaline/ea.
I loko o nā ʻāpana alkaline aluminika / ea, hiki i ka dithiothreitol ke hana i kahi ʻāpana pale a paʻa ma o nā covalent paʻa ikaika ma ka ʻili o ka anode aluminika, ke kāohi i ka hoʻomāinoino ponoʻī o ka anode alumini, a hoʻomaikaʻi maikaʻi i kāna hana.