Penicillin G potassium paʻakai CAS:113-98-4 99% ʻO ka pauka keʻokeʻo
| Helu Helu | XD90351 |
| inoa mea kūʻai | ʻO ka paʻakai pālolo penicillin G |
| CAS | 113-98-4 |
| ʻĀpana Molekala | C16H17KN2O4S |
| Kaumaha Molecular | 372.48 |
| Nā kikoʻī mālama | Ambient |
| Kānāwai Kūʻai Kūlike | 29411000 |
Huahana Huahana
| Nalo ma ka maloo | <1.0% |
| Ke kala o ka Haʻina | ʻAʻole i ʻoi aku ka ikaika o ka kala ma mua o ka ikaika Y2 a i ʻole YG2 o ka laulā o ka ʻōlelo |
| pH | 5-7.5 |
| Na mea pili | <1.0% |
| Hoʻāʻo | 99% |
| Ka mana | 1440 - 1680u/mg |
| Ka nana aku | Keʻokeʻo a aneane keʻokeʻo crystalline pauda |
| Akaka o ka Haʻina | ʻAʻole i ʻoi aku ma mua o ka opalescent ma mua o ka hoʻokuʻu ʻia ʻana 1 |
| Ka lawe ʻana | NLT 90% |
| Butyl acetate | NMT 0.05% |
| Butanol | NMT 0.12% |
e wehewehe mua ʻia kahi mole autoinducer, i ʻike ʻia ʻo 1,3-diaminopropane (1,3-DAP), i hūnā ʻia e Penicillium chrysogenum a me Acremonium chrysogenum.Ma ka hoʻohana ʻana i nā moʻomeheu fermentor pH-controlled, ua ʻike mākou ma kēia hana ʻo 1,3-DAP a me spermidine e hoʻoikaika maopopo i ka biosynthesis o benzylpenicillin i P. chrysogenum, ma nā mea i wehewehe ʻia a i loko o ka pāpaʻi penicillin paʻakikī.ʻO ka 1,3-DAP a me ka spermidine, akā ʻaʻole putrescine (1,4-diaminobutane), e hoʻonui nui i nā pae transcript o nā penicillin biosynthetic genes pcbAB, pcbC a me penDE.ʻAʻole pili kēia mau polyamines i ka hōʻike o ka honua pH-stress regulator pacC gene, no laila e kāpae ʻia ka hopena o ka 1,3-DAP a me ka spermidine ma muli o ka hoʻololi ʻana i ka ʻōnaehana pH control.Hoʻemi nui ʻia ka hōʻike ʻana o nā genes biosynthetic penicillin ʻekolu i loko o kahi mutant laeA-knock-down o P. chrysogenum, kahi e hoʻopuka ai i nā pae haʻahaʻa loa o benzylpenicillin.ʻO ka mea hoihoi, hoʻihoʻi ka 1,3-DAP a me ka spermidine i ka hopena o ka laeA knock-down mutation, e hoʻihoʻi loa i nā pae o ka hana penicillin.Eia kekahi, ua hoʻonui ka 1,3-DAP a me ka spermidine i ka hōʻike ʻana o ka laeA i ke koʻikoʻi makua a hoʻihoʻi i nā pae o ka laeA transcripts i ka laeA knock-down mutant.Hoʻopili pū ʻia kēia mau hopena e hōʻike ana i ka hopena stimulatory o nā molekele inducer 1,3-DAP a me ka spermidine e hoʻokō ʻia, ma ka liʻiliʻi loa, ma o ka hoʻoulu ʻana o ka laeA, he mea hoʻoponopono honua e hana epigenetically ma ka hōʻike ʻana o nā genes metabolite lua. e ka heterochromatin hoʻonohonoho hou.
