Nā huahana

No ka ʻimi ʻana i nā mea hana anticancer hou e pili ana i ka platinum i ʻokoʻa mai ke ʻano a me ke ʻano pili o ka cisplatin kuʻuna ma o ka hoʻokumu ʻana i ka bifunctional intrastrand 1,2 GpG addduct, ua aʻo ʻia ka monofunctional platinum+DNA adducts me ka nui o nā pilina non-covalent.Ua hōʻike ʻia ʻo ka monofunctional testosterone-based platinum(II) agents e hōʻike i ka hana anticancer kiʻekiʻe.Eia kekahi, ua ʻike ʻia e hiki i nā mea hana platinum i hoʻokumu ʻia i ka testosterone ke hana i ka helix DNA e hana i ka unwinding nui a me ke kūlou ʻana ma luna o nā mea hana platinum non-testosterone.Eia nō naʻe, ʻaʻole maopopo i kēia manawa nā hana pili o kēia mau mea platinum me DNA ma ka pae atomic. ʻO ka platinum + DNA i hoʻokumu ʻia, ka platinum + DNA i hoʻokumu ʻia i ka testosterone i hoʻomaikaʻi ʻia a me ka hoʻohui ʻana o ka platinum+DNA non-testosterone.Hōʻike nā hualoaʻa i ka pilina intercalative o ka mea i hoʻomaikaʻi ʻia i ka testosterone-based platinum agent me ka mole DNA hiki ke hoʻoulu i ka distortion conformational DNA nui aʻe ma mua o ka launa pū ʻana o ka mea hana platinum i hoʻokumu ʻia me ka mole DNA.ʻO nā noiʻi hou aʻe no ka mea hana platinum non-testosterone e hōʻike ana i ka hiki ʻana mai o ka loli liʻiliʻi o ka conformation DNA ma muli o ka loaʻa ʻole o ka ligand testosterone i loko o ia mea.Ma muli o ka DNA dynamics analysis, ua kamaʻilio pū ʻia nā moʻo kumu DNA e pili ana i ka hoʻololi ʻana i ka ʻāpana DNA groove a me ka luku ʻana i ka paʻa hydrogen o nā hui kumu DNA. ʻO ka hoʻohui ʻana o ka platinum + DNA i hoʻonui ʻia i ka testosterone, ʻokoʻa ia mai ka launa pū ʻana o ke alo i hana ʻia e kahi mea hoʻopili paʻa i loko o ka mea hana platinum e pili ana i ka testosterone.Hāʻawi nā noiʻi i kēia manawa i ka ʻike kūpono o ka conformation DNA i hoʻopili ʻia e kahi paʻakikī platinum e pili ana i ka testosterone ma ka pae atomika.