Nā huahana

ʻO ka hoʻololi ʻana i ka eucine-rich repeat kinase 2 (LRRK2) ke kumu maʻamau o ka maʻi o Parkinson (PD).ʻAʻole hiki ke ʻike ʻia nā hiʻohiʻona o ka LRRK2 PD mai ka idiopathic PD, me ka hōʻiliʻili ʻana o ka α-synuclein a me / a i ʻole tau a me / a i ʻole ubiquitin i loko o ka intraneuronal aggregates.Hōʻike kēia he kī nui ʻo LRRK2 i ka hoʻomaopopo ʻana i ka aetiology o ka maʻi.ʻOiai ʻaʻole ʻike ʻia ka nalowale o ka hana ʻo ia ke kumu o ka PD i nā maʻi maʻi LRRK2, ʻaʻole maopopo i ke ʻano o kēia protein e hoʻopili ai i ka ʻona.Ma kēia haʻawina, hōʻike mākou i ka overexpression LRRK2 i loko o nā cell a i loko o ka vivo e hoʻopilikia i ka hana o ke ala ubiquitin-proteasome, a ʻo kēia ka helu no ka hōʻiliʻili ʻana o nā substrates like ʻole me ka overexpression LRRK2.Hōʻike mākou ʻaʻole i hoʻopili ʻia kēia e nā aggregates LRRK2 nui a i ʻole sequestration o ubiquitin i nā aggregates.ʻO ka mea nui, ʻaʻole ʻike ʻia kēlā mau mea ʻino me ka overexpression o ka protein pili LRRK1.Hōʻike kā mākou ʻikepili i ka LRRK2 e kāohi i ka hoʻomaʻemaʻe ʻana o ka substrate proteasome ma luna o ka hana catalytic proteasome, e makemake ana i ka hōʻiliʻili ʻana o nā protein a me ka hoʻokumu ʻana.No laila, hāʻawi mākou i kahi loulou molekala ma waena o LRRK2, ke kumu maʻamau i ʻike ʻia o PD, a me kāna phenotype i wehewehe mua ʻia o ka hōʻiliʻili protein.