Nā huahana

ATP-gates P2X3 receptors mea nui transducers o nociceptive stimuli a ua aneane hoike wale ia e sensory ganglion neurons.I loko o ka mouse trigeminal ganglion (TG), hoʻonui ʻia ka hana receptor P2X3 e ka pharmacological block of natriuretic peptide receptor-A (NPR-A), e hōʻike ana i kahi hana inhibitory o nā peptides natriuretic endogenous i ka nociception i hoʻopili ʻia e nā mea hoʻokipa P2X3.ʻO ka hemahema o ka hoʻololi ʻana i ka ʻōlelo protein P2X3 e hōʻike ana i kahi modulation paʻakikī nona nā hana no ka hoʻohaʻahaʻa ʻana i ka hana o ka receptor P2X3 i maopopo ʻole. mea pale anantin.No laila, ua noiʻi mākou i nā loli i ka hāʻawi ʻana i ka receptor P2X3 i ka ʻāpana lipid raft membrane, ko lākou kūlana phosphorylation, a me kā lākou hana me ka hoʻopili ʻana.ʻO ka hoʻomaka ʻana o ka hoʻomaka ʻana o ka desensitization P2X3 kekahi mea hana no ka hoʻonui ʻana i ka anantin i ka hana P2X3.ʻO ka Anant i ka noi i hoʻokaʻawale hou ʻia ka mea hoʻokipa P2X3 i ka ʻāpana raft lipid a hoʻemi i ka phosphorylation serine P2X3, ʻelua mau mea i pili ʻole.An inhibitor o cGMP-hilinaʻi pūmua kinase a me siRNA-mediated knockdown o BNP mimicked ka hopena o anantin.We hōʻike i loko o ka iole trigeminal neurons endogenous BNP hana ma NPR-A receptors e hooholo constitutive kaumaha o P2X3 receptor hana.ʻO ka hoʻopaʻa ʻana i ka hana hoʻokipa P2X3 e nā ala BNP/NPR-A/PKG e hana ʻia ma o ʻelua mau ʻano hana like ʻole: P2X3 serine phosphorylation a me ka hāʻawi hou ʻana i nā ʻāpana membrane non-raft.ʻO kēia kaʻina hana hou o ka mana o ka mea hoʻokipa hiki ke lilo i pahuhopu no nā noiʻi e hiki mai ana e hoʻemi ana i ka hana hoʻokipa P2X3 dysregulated i ka ʻeha mau.