Nā huahana

(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)methanone, ʻike ʻia hoʻi ʻo CF3-112, he mea hoʻohui kemika me kekahi mau noi koʻikoʻi i ke kahua o ka lāʻau lapaʻau a me ka lāʻau lapaʻau. ka hoʻomohala ʻana. ʻO kekahi o nā hoʻohana nui o CF3-112 ma ke ʻano he kinase inhibitor.ʻO Kinases nā enzymes e hoʻoponopono i nā kaʻina cellular like ʻole i loko o ke kino, me ka ulu ʻana o ka cell, ka māhele, a me ke kamaʻilio.Hoʻopili pinepine ʻia ka dysregulation o kinases me nā maʻi e like me ke kanesa a me nā maʻi autoimmune.Ua ʻike ʻia ʻo CF3-112 e hōʻike i ka hana hoʻoweliweli ikaika e kūʻē i kekahi mau kinases, e lilo ana ia i moho hoʻohiki no ka hoʻomohala ʻana i nā lāʻau lapaʻau. ua hōʻike pinepine ʻia i nā maʻi kanesa.Ma ke koho ʻana a me ka pale ʻana i kēia mau kinases, hiki i ka CF3-112 ke kōkua i ka hoʻopau ʻana i ka ulu wikiwiki ʻana o nā maʻi kanesa a hiki ke hāʻawi i kahi pōmaikaʻi therapeutic. nā maʻi ʻino e like me ka leukemia myeloid acute (AML) a me nā neoplasms myeloproliferative.ʻO ka pale ʻana i kēia mau kinases me CF3-112 hiki ke hoʻopau i nā ala hōʻailona e alakaʻi i ka ulu a me ke ola ʻana o nā maʻi kanesa, e hāʻawi ana i nā mea hou no ka mālama ʻana i kēia mau maʻi. - nā hopena ʻeha.ʻO ka līlū he pane olaola paʻakikī e pāʻani ana i nā maʻi he nui, me nā maʻi autoimmune a me nā kūlana inflammatory mau.Ua hōʻike ʻo CF3-112 i ka ʻōlelo hoʻohiki ma ke ʻano he mea pale i kekahi mau ala inflammatory, hiki ke hāʻawi i kahi ala lapaʻau no ka mālama ʻana i kēia mau kūlana. profile, a me ka noi kūpono.E like me ka hui pū ʻana, koi ʻia ka hoʻāʻo ikaika a me nā haʻawina preclinical ma mua o ka hiki ke holomua i nā hoʻokolohua lapaʻau kanaka.ʻO kāna hana kinase inhibitory, e kūʻē i ka Aurora kinases, FLT3, a me JAK2, hoʻonoho iā ia ma ke ʻano he moho kūpono no ka hoʻomohala ʻana i nā lāʻau lapaʻau i manaʻo ʻia no ka maʻi kanesa a me nā maʻi maʻi hematological.Hōʻike pū kāna mau waiwai anti-inflammatory i nā noi kūpono i ka mālama ʻana i nā maʻi autoimmune a me nā kūlana inflammatory mau.Eia nō naʻe, pono ka noiʻi hou e wehe i kona hiki ke hoʻōla piha a loiloi i kona palekana a me ka pono.