Nā huahana

ʻO ke kālā trifluoromethanesulfonate, i ʻike ʻia ʻo AgOTf, he reagent ikaika a maʻalahi hoʻi i hoʻohana ʻia i nā loli kemika.Aia ia i ka papa o nā triflates metala, he mea pono loa ia i ka synthesis organik ma muli o kā lākou Lewis acidity a me ka hiki ke hoʻāla i nā substrates.Hiki iā ia ke hoʻololi i nā ʻano hoʻololi like ʻole, e like me ke kalapona-carbon bond forming reactions, e like me ka Friedel-Crafts alkylation and acylation reactions, a me ka carbon-nitrogen bond forming reactions, e like me ka N-acylation o nā amine a i ʻole ka synthesis o nā amides.ʻO ka Lewis acidic ʻano o AgOTf hiki iā ia ke hui pū me nā substrates waiwai electron, e alakaʻi ana i ka hoʻōla ʻana i nā mea paʻa kemika kikoʻī a hoʻomaʻamaʻa i ka hopena i makemake ʻia.He waiwai nui kāna hana catalytic i ka synthesis o nā lāʻau lapaʻau, agrochemical, a me nā kemika maikaʻi. He mea maikaʻi nō hoʻi ʻo AgOTf i ka hoʻolalelale ʻana a me nā hopena cyclization.Hiki iā ia ke hoʻololi i nā ʻano like ʻole, e like me ka Beckmann rearrangement, ka mea e hoʻohuli ai i nā oximes i amides a i ʻole esters, a i ʻole ka hoʻonohonoho hou ʻana o nā ʻona allylic e hana i nā pūhui carbonyl.Eia hou, hiki iā ia ke kōkua i nā hopena cyclization, hiki ke hoʻokumu i nā pūhui cyclic me nā ʻōnaehana apo paʻakikī.He kuleana koʻikoʻi ka Lewis acidic o AgOTf i kēia mau hopena ma o ka hoʻomaʻamaʻa ʻana i ka hoʻoponopono hou ʻana i nā mea pili pono a me nā ʻanuʻu cyclization.Hiki iā ia ke hoʻoikaika i nā paʻa CH e pili ana i nā pūʻulu hana, e like me ka hoʻāla ʻana o nā mea hoʻopaʻa CH aromatic a i ʻole ka hoʻāla ʻana o nā paʻa CH allylic a benzylic paha.Hiki i kēia ho'ā 'ana no ka hoʻohana hou ʻana o ka paʻa CH, e alakaʻi ana i ka hoʻokumu ʻana i nā paʻa carbon-carbon a i ʻole carbon-heteroatom hou.ʻO kēia ala, i kapa ʻia ʻo CH activation, he māla ulu wikiwiki i ka synthesis organik a hāʻawi i kahi ala kūpono e komo ai i nā scaffolds molecular paʻakikī.Hoʻohana maʻamau ia i nā mea liʻiliʻi, e like me nā helu catalytic, ma muli o kona kiʻekiʻe reactivity.Pono e mālama i ka hana ma kahi e hoʻoheheʻe maikaʻi ʻia a me ka pale ʻana i ka reagent mai ka ʻike ʻana i ka maʻa.ʻO kona ʻano ʻakika Lewis e hiki ai iā ia ke hoʻāla i nā substrates, hoʻoikaika i ka hoʻonohonoho hou ʻana a me nā hopena cyclization, a hoʻāla i nā paʻa CH, e alakaʻi ana i ka hoʻokumu ʻana i nā molekala organik paʻakikī.Eia nō naʻe, pono e mālama ʻia ka mālama ʻana a me ka mālama ʻana iā AgOTf e hōʻoia i kona kūpaʻa a pale i nā hopena makemake ʻole.