Tazobactam Cas: 89786-04-9
| Helu Helu | XD92373 |
| inoa mea kūʻai | ʻO Tazobactam |
| CAS | 89786-04-9 |
| ʻAno Molekalala | C10H12N4O5S |
| Kaumaha Molekala | 300.29 |
| Nā kikoʻī mālama | -15 a -20 °C |
| Kānāwai Kūʻai Kūlike | 29419000 |
Huahana Huahana
| Ka nana aku | ʻO ka pauka keʻokeʻo keʻokeʻo |
| ʻO Assay | 99% min |
| Wai | <0.5% |
| Kahuli kiko'ī | +127 a i +139 |
| Nā metala kaumaha | <20ppm |
| Koena ma ka Ignition | <0.1% |
| Huina paumaele | <1.0% |
ʻO Tazobactam kahi sulfone penicillanic acid e like me ka sulbactam.ʻOi aku ka ikaika o ka β-lactamaseinhibitor ma mua o ka sulbactam a ʻoi aku ka nui o ka hana spectrumof ma mua o ka clavulanic acid.He nawaliwali loa kona antibacterialactivity.Loaʻa ka Tazobactam i ka paʻa paʻa, injectable hui pū me ka piperacillin, kahi penicillin ākea ākea e pili ana i ka ratio 8: 1 o ka piperacillin sodium i ka tazobactamsodium ma ke kaumaha a kūʻai ʻia ma lalo o ka inoa kālepa Zosyn. ʻO nā pharmacokinetics o nā lāʻau lapaʻau ʻelua like loa.He pōkole ko lāua mau hapalua ola (t1/2 ～1 hola), liʻiliʻi loa ka protein, ʻike liʻiliʻi loa ka metabolism, a ua hoʻokuʻu ʻia i nā ʻano hana ʻole i loko o ka mimi i nā kiʻekiʻe kiʻekiʻe.
ʻO nā hōʻailona i ʻāpono ʻia no ka hui ʻana o ka piperacillin-tazobactam me ka mālama ʻana i ka appendicitis, postpartumendometritis, a me ka maʻi ʻeha pelvic i hoʻokumu ʻia e ka β-lactamase-producing E. coli a me Bacteroides spp., nā maʻi ʻili a me ka ʻili i hoʻokumu ʻia e β-lactamase-producingS.aureus, a me ka ma'i ma'i ma muli o ka β-lactamase-producing strains o H. influenzae.
