Nā huahana

Ua hoʻokuʻu mua ʻia ʻo Telithromycin ma Kelemania ma ke ʻano he lāʻau lapaʻau waha i kēlā me kēia lā no nā maʻi hanu e like me ka pneumonia i loaʻa i ke kaiāulu, nā maʻi bacterial exacerbations o ka bronchitis maʻi, ka sinusitis a me ka tonsillitis/pharyngitis.ʻO kēia semisynthetic derivative o ka macrolide erythromycin maoli ka ketolide kūʻai mua ʻia, kahi papa hou o nā lāʻau antibiotic e hōʻike ana i kahi C3-ketone ma kahi o ka hui L-cladinose.ʻO ka 14-membered ring antibacterial agent e pale i ka synthesis protein bacteria ma ka hoʻopaʻa ʻana i ʻelua mau kikowaena o ka subunit 50S o nā ribosomes bacterial.Hōʻike ia i ka hana in vitro ikaika e kūʻē i nā pathogen respiratory maʻamau e like me Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis a me Streptococcus pyogenes a me nā pathogens atypical ʻē aʻe.Hāʻawi ka hui 3-keto i ka hoʻonui ʻana i ka waikawa a me ka hoʻohaʻahaʻa ʻana i ka pale ʻana o ka macrolide-lincosamide-streptogramin B i ʻike pinepine ʻia me nā macrolides.ʻO ke koena carbamate C11-C12 i hoʻololi ʻia ʻaʻole wale e hoʻonui i ka pilina no ka pūnaewele hoʻopaʻa ribosomal akā no ka hoʻopaʻa ʻana i ka pūhui e kūʻē i ka esterase hydrolysis a pale i ke kū'ē ʻana ma muli o ka hoʻopau ʻia ʻana o nā macrolides mai ke kelepona e kahi pā efflux i hoʻopili ʻia e ka mef gene i kekahi mau pathogens. .ʻO Telithromycin kahi mea hoʻokūkū hoʻokūkū a me kahi substrate o CYP3A4.Eia nō naʻe, ʻaʻole like me nā macrolides e like me troleandomycin, ʻaʻole ia e hana i kahi paʻa paʻa paʻa CYP P-450 Fe2+-nitrosoalkane metabolite paʻakikī i hiki ke hepatotoxic.Hoʻomaʻamaʻa maikaʻi ʻia ka lāʻau lapaʻau a hāʻawi maikaʻi ʻia i loko o nā ʻiʻo pulmonary, bronchial secretions, tonsils a me saliva.Ua lilo ia i mea nui loa i loko o ka azurophil granules o polymorphonuclear neutrophils e hoʻomaʻamaʻa i kona lawe ʻana i ka bacteria phagocytosed.