Nā huahana

Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino) ʻO pyridin-3-yl) piperazine-1-carboxylate kahi hui me ka mana nui i ka lāʻau kemika a me ka hoʻomohala ʻana i ka lāʻau.Hōʻike kona ʻano molekala paʻakikī i nā ʻano like ʻole o nā noi. Aia i loko o kēia pūhui kahi piperazine-1-carboxylate core, kahi scaffold maʻamau i hoʻohana ʻia i ka lāʻau kemika ma muli o kona ʻano versatile a me ka laulā o nā mea hiki i ka lāʻau lapaʻau.ʻO ka heleʻana o ka piperazine moiety e hiki ai i nā pilina me nā mea loaʻa likeʻole a me nā enzymes, e lilo ia i moho hoihoi no ka hoʻomohalaʻana i nā mea lapaʻau. ʻO 8-dihydropyrido [2,3-d] pyrimidin-2-yl pūʻulu i loko o ka hale e hāʻawi i ka hana pharmacological hiki.Ua aʻo nui ʻia kēlā mau pyrido [2,3-d] pyrimidine derivatives no kā lākou anti-inflammatory, antiviral, a me anticancer properties.Hāʻawi ka hui cyclopentyl a me methyl i ka lipophilicity o ka pūhui, hiki ke hoʻonui i kona cellular permeability a me ka bioavailability. ʻO ka hui tert-butyl ester e hāʻawi i ka paʻa i ka hui a hiki ke maʻalahi i ka hoʻololi ʻana i nā hui hana ʻē aʻe, e ʻae ai i nā hoʻololi hou a i ʻole derivatization.He mea waiwai kēia maʻalahi i ka kemika lāʻau lapaʻau, no ka mea e hiki ai i ka hoʻomohala ʻana i nā mea hoʻohui ʻoi aku ka ikaika a me ka koho.Hōʻike kēia i ka hopena o ka hui i nā ala hōʻailona intracellular a hiki ke ʻimi hou ʻia no kona hiki ke ʻano modulator a i ʻole antagonist o nā mea loaʻa kikoʻī e pili ana i nā kūlana maʻi. (1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate kona hiki i ka hoʻomohala ʻana i nā therapeutics hou.Hāʻawi ia i nā manawa e noiʻi ai i ka enzyme inhibition, receptor binding, a me ka hoʻololi ʻana o nā kaʻina hana olaola like ʻole.ʻO kāna mau hiʻohiʻona kūikawā a me nā hana olaola hiki ke lilo ia i mea hoihoi no ka noiʻi hou a me ka hoʻomohala ʻana i ke kahua o ka lāʻau kemika. ʻO 5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate paʻa i ka ʻōlelo hoʻohiki ma ke ʻano he hui versatile no ka hoʻomohala lāʻau.ʻO kāna ʻano paʻakikī a me nā hana lāʻau lapaʻau hiki ke lilo i moho hoihoi no ka hoʻokolokolo hou ʻana ma ke ʻano he lāʻau lapaʻau kūpono no nā maʻi like ʻole a me nā kūlana.