Tiamulin 98% Cas: 125-65-5
| Helu Helu | XD91893 |
| inoa mea kūʻai | Tiamulin 98% |
| CAS | 125-65-5 |
| ʻAno Molekalala | C22H34O5 |
| Kaumaha Molecular | 378.5 |
| Nā kikoʻī mālama | -20°C |
| Kānāwai Kūʻai Kūlike | 2918199090 |
Huahana Huahana
| Ka nana aku | Pauda keʻokeʻo |
| ʻO Assay | 99% min |
| Lae hehee | 170-1710C |
| alpha | D24 +20° (c = 3 in abs ethanol) |
| Lae paila | 482.8±45.0 °C(Wānana ʻia) |
| mānoanoa | 1.15±0.1 g/cm3(Wānana ʻia) |
| hikiwawe | DMSO: >10mg/mL (mehana) |
| pka | 12.91±0.10(Wānana ʻia) |
| hana ʻōpika | [α]/D +30 a i +40° (c=1; CH2Cl2) |
ʻO Pleuromutilin kahi diterpene i hana ʻia e kekahi mau ʻano basidomycete, ʻo ia hoʻi ka genus Pleurotus, i ʻike ʻia i ka makahiki 1951. ʻO Pleuromutilin kahi lāʻau antibiotic ikaika a koho maikaʻi loa e kūʻē i kahi ʻano o nā bacteria Gram positive, me ke kūʻē ʻole i nā papa lāʻau antibiotic ma muli o kāna ʻano kūʻokoʻa. o ka hana.Hoʻopaʻa ʻo Pleuromutilin i ka synthesis protein ma o ka hoʻopaʻa ʻana i ka domain V o 23S rRNA a ua alakaʻi kēia i ka hoʻomohala ʻana o nā analogues semi-synthetic he mau lāʻau antibiotic hou, e like me tiamulin a me retapamulin.
Ua hoʻohana ʻia nā Pleuromutilins e like me tiamulin a me valnemulin no kekahi manawa i ka lāʻau lapaʻau holoholona e mālama i nā maʻi puaʻa.I kēia mau lā, ua hoʻokomo ʻia kahi pleuromulin semisynthetic, retapamulin, ma ke ʻano he lāʻau lapaʻau no nā maʻi Gram-positive i loko o ke kanaka.Kāohi ʻo Pleuromutilins i ka hana peptidyl transferase o ka 50S ribosomal subunit ma ka hoʻopaʻa ʻana i ka pūnaewele A.
