Nā huahana

ʻO Trans-1-(tert-Butoxycarbonyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid he mea hoʻohui kemika i loaʻa nā noi like ʻole i ke kahua o ka synthesis organik a me ka noiʻi lāʻau lapaʻau.Hōʻike ʻia ia e ka loaʻa ʻana o kahi apo pyrrolidine i pani ʻia me kahi hui pale tert-butoxycarbonyl (Boc) ma ka atom nitrogen a me kahi hui trifluoromethyl ma ke apo phenyl. ʻO ka 4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid he mea waena i ka synthesis o nā mea hoʻohuihui ʻē aʻe.ʻO kona hoʻolālā kūʻokoʻa a me nā pūʻulu hana e lilo ia i poloka hale maʻalahi no ke kūkulu ʻana i nā molekala paʻakikī.He pūʻulu pale ka hui Boc, hiki ke hoʻoneʻe ʻia ma lalo o nā kūlana hoʻohālikelike kikoʻī e hōʻike i ka pae reactive no ka hoʻololi hou ʻana.Hāʻawi kēia i nā hoʻololi kūlohelohe a pololei. ʻO ka hui trifluoromethyl i trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid e hāʻawi pū i nā waiwai nui a me nā noi kūpono.ʻIke ʻia nā hui Trifluoromethyl no kā lākou electron-withdrawing ʻano a me ka lipophilicity, hiki ke hoʻonui i ka potency, metabolic stability, a me ka bioavailability o nā moho lāʻau.Eia hou, hiki i ka hui trifluoromethyl ke hoʻololi i nā waiwai physicochemical o ka pūhui, e pili ana i ka solubility, lipophilicity, a me ka mea hoʻopaʻa paʻa i ka pilina. Hiki i ka waikawa carboxylic ke hōʻike i ka hana ola kino a i ʻole ma ke ʻano he prodrug.ʻO nā Prodrugs nā pūhui hana ʻole i loko o ke kino e hoʻololi ʻia i loko o ke kino e hoʻololi i nā lāʻau ikaika.I kekahi mau hihia, hiki ke hoʻoneʻe ʻia ka hui pale Boc i loko o ka vivo, e hoʻāla ana i ka pūhui e kiʻi i kahi hopena therapeutic i makemake ʻia. He nui ka phenyl)pyrrolidine-3-carboxylic acid, pono ka noiʻi hou ʻana a me ka noiʻi e ʻimi i kona hiki piha.Hoʻopili maʻamau kēia i ka loiloi kemika lāʻau lapaʻau, nā haʻawina pili i ka hana-hana, a me ka loiloi olaola.Ma ka hoʻomaopopo pono ʻana i nā waiwai a me ka hana ʻana o ka pūhui, hiki i nā ʻepekema ke loiloi i kona kūpono no ka huli ʻana i nā maʻi a i ʻole nā ​​kūlana kūikawā, e alakaʻi ana i ka hoʻomohala ʻana i nā moho lāʻau hou a i ʻole nā ​​​​mea catalytic i ka wā e hiki mai ana.