Nā huahana

ʻO ka noiʻi phytochemical o ka mea kanu holoʻokoʻa o Lepisorus contortus (Christ) Ching i alakaʻi i ka hoʻokaʻawale ʻana i ʻelima mau glycosides phenylethanoid hou (1-5), i loko o kēlā me kēia me kahi hui caffeoyl, kahi flavonoids glycoside hou (10), a me 14 mau pūhui i ʻike ʻia (6-9). a me 11-15, ʻakika syringic, ʻakika vanillic, ʻakika phloretic, diplopterol, a me β-sitosterol).ʻO kēia ka hōʻike mua o nā glycosides phenylethanoid mai ka ʻohana Polypodiaceae.Ua loiloi ʻia nā pūʻulu 1-15 no ko lākou hiki kemopreventive maʻi kanesa e pili ana i ko lākou hiki ke keʻakeʻa i ka necrosis factor alpha (TNF-α) -induced NF-κB hana, hana nitric oxide (NO), a me ka aromatase, quinone reductase 2 (QR-2). ), a me nā hana COX-1/-2.Ua hōʻike ʻo Quercetin-3-O-β-d-glucoside (15) i ka pale ʻana i ka QR2 me kahi waiwai IC (50) o 3.84 μM, nāna i hōʻoia i ka kaempferol/quercetin glycosides ma ke ʻano he pūhui hana e kāohi ai i ka QR2.Ua hōʻike pū ka pūhui i ka hana NF-κB me kahi waiwai IC(50) o 33.6 μM.Eia hou, ua hōʻike nā pūhui 1, 2, 4, a me 6 i ka hana ar omatase me IC(50) waiwai o 30.7, 32.3, 26.8, a me 35.3 μM.