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ʻO 1-(3-Hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine kahi hui kemika me kahi ākea ākea o nā noi i ka lāʻau lapaʻau a me ka hoʻomohala ʻana i ka lāʻau. , pili i ka ʻike lāʻau.ʻO ka loaʻa ʻana o ka hui hydroxymethylpyridinyl e hōʻike ana i ka launa pū ʻana me nā pahuhopu olaola kikoʻī, e like me nā enzymes a i ʻole nā ​​​​mea hoʻokipa.Hiki i nā lāʻau lapaʻau ke hoʻoikaika i ke ʻano o kēia pūhui e hoʻonui ai i kona pilina paʻa a me ke koho ʻana i nā pahuhopu olaola i makemake ʻia.Ma ka hoʻololiʻana i ka phenyl a me ka piperazine moieties, hiki i nā mea noiʻi ke hoʻoponopono maikaʻi i nā waiwai physicochemical a me nā pharmacokinetics o ka pūpū, hiki ke alakaʻi i ka maikaʻi o ka lāʻau lapaʻau a hoʻemi i nā hopena i makemakeʻoleʻia. Aia ka -methyl-2-phenylpiperazine ma ke kahua o ka neuropharmacology.Hōʻike ke ʻano o kēia pūhui i ka launa pū ʻana me nā mea loaʻa i ka ʻōnaehana nūnū waena, hiki ke alakaʻi i nā hopena therapeutic i nā maʻi neurological.No ka laʻana, hiki ke ʻimi ʻia ma ke ʻano he moho no ka hoʻololi ʻana i ka neurotransmission i nā kūlana e like me ka hopohopo, ke kaumaha, a me ka schizophrenia.Hiki i nā mea noiʻi ke noiʻi i ke ʻano hana o ka pūhui a hana i nā noiʻi preclinical a me nā noiʻi lapaʻau e loiloi i kona hiki ke hoʻōla.ʻO kāna mau pūʻulu phenyl a me methyl hydrophobic e hōʻike ana i ka hiki ke hele i nā membrane lipid, hiki iā ia ke kuhikuhi i nā enzyme intracellular a i ʻole nā ​​ala.He mea maikaʻi kēia waiwai no ka hoʻomohala ʻana i nā lāʻau lapaʻau e pono ai ke komo i nā cell a hoʻokō i kā lākou hopena i nā pahuhopu intracellular kikoʻī.Ma ka hoʻololi ʻana i ke ʻano o ka pūhui, hiki i nā lāʻau lapaʻau ke hoʻonui i kona bioavailability, hoʻomaikaʻi i kona kūpaʻa, a hoʻomohala i nā hoʻolālā hoʻopuka lāʻau maikaʻi. -phenylpiperazine i loko o kēia mau noi hiki ke koi i nā loiloi preclinical a me nā loiloi koʻikoʻi e hōʻoia i ka palekana, ka pono, a me ke ʻano kūpono.Pono nā haʻawina pharmacological a me toxicological nui e hoʻomaopopo i kona hopena i nā ʻōnaehana olaola like ʻole a me ka hoʻoholo ʻana i nā hopena maikaʻi ʻole. hiki i nā noi i ka lāʻau kemika a me ka hoʻomohala lāʻau.Paʻa ia i ka hoʻohiki no ka hoʻolālā ʻana i nā lāʻau lapaʻau hou, ʻoi aku hoʻi i nā wahi o ka neuropharmacology a me ka lawe ʻana i ka lāʻau.Pono nā noiʻi hou aʻe e ʻimi i kāna mau pilina kikoʻī, ka hana o ka hana, a me ka hiki ke therapeutic, e hoʻokaʻawale i ke ala no nā mea hiki ke holomua i ka mālama ʻana i nā maʻi like ʻole a me nā pilikia.