Nā huahana

4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]- ʻO ka piperazine-1-carboxylic acid tert-butyl ester he hui me ka hiki ke hoʻohana i ka noiʻi lāʻau lapaʻau a me ka hoʻomohala lāʻau.Hāʻawi kona ʻano paʻakikī a me nā hui hana i nā manawa like ʻole no ka noiʻi ʻana a me ka ʻimi ʻana i kāna mau noi therapeutic.ʻO ka heleʻana o ka hui bromo a me ka pyrido [2,3-d] pyrimidin moiety e hōʻike ana he hana anti-cancer.Ua ʻike ʻia ka pūʻulu bromo no kona hiki ke kāohi i ka ulu ʻana o ka cellular a hoʻoulu i ka apoptosis i nā maʻi maʻi.Eia hou, ua pili ka pyrido [2,3-d] pyrimidin scaffold me nā hopena anti-proliferative a me ka anti-tumor.No laila, hiki ke aʻo hou ʻia kēia pūhui no kona hiki ke lilo i mea anti-cancer agent. -pale lolo.Ke wehe nei kēia waiwai i ka hiki ke hoʻohana iā ia i ka hoʻomohala ʻana i nā lāʻau lapaʻau e kuhikuhi ana i nā maʻi o ka ʻōnaehana nerve waena, e like me nā maʻi neurological.Hiki ke hoʻololiʻia ka pūhui e hoʻonui i kona koho a me ka mana e kū'ē i nā mea kiko'ī e pili ana i kēia mau maʻi.ʻO Prodrugs nā pūhui hana ʻole i hiki ke hoʻololi ʻia i mau ʻano hana i loko o ke kino.Hiki i ka hui tert-butyl ester ke lawelawe ma ke ʻano he pūʻulu pale, e pale ana i ka hoʻōla mua ʻana o ka lāʻau lapaʻau ma mua o ka hiki ʻana i ke kahua o ka hana i makemake ʻia.I ka manawa e hiki ai i ka ʻiʻo a i ʻole nā ​​​​pūnaewele, hiki ke hoʻokaʻawale ʻia ka hui ester, e hoʻokuʻu ana i ka molekele lāʻau ikaika.Hiki i kēia mau mea mai kinases a i G protein-coupled receptors, ma muli o nā hoʻololi i hana ʻia i ke ʻano kumu.Hiki i kēia pūhui ke lilo i wahi hoʻomaka no nā haʻawina pili i ka hoʻolālā-hana a me ke alakaʻi maikaʻi ʻana e hoʻomohala i nā mea hoʻopaneʻe ikaika a koho no nā pahuhopu therapeutic kikoʻī. -oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester e hōʻike ana i ka hiki i nā wahi like ʻole o ka noiʻi lāʻau lapaʻau.Hiki ke ʻimi hou ʻia kona ʻano kūʻokoʻa a me nā pūʻulu hana no ka hana anti-cancer, ka hoʻomohala ʻana i ka lāʻau lapaʻau ma waena o ka ʻōnaehana, nā hoʻolālā prodrug, a me ka enzyme koho a i ʻole ka ʻae ʻana i ka loaʻa.ʻO ka hoʻomau ʻana i ka noiʻi ʻana a me ka loiloi ʻana o kēia pūhui ke alakaʻi i ka ʻike ʻana i nā koho therapeutic hou me ka hoʻomaikaʻi maikaʻi a me ka kikoʻī kikoʻī.