Nā huahana

ʻO (2-Chloro-5-iodophenyl) (4-fluorophenyl) methanone, i kapa ʻia ʻo CF12, he hui kemika me nā noi like ʻole i ka noiʻi lāʻau lapaʻau a me ka synthesis. a i ʻole waena no ka hoʻohuihui ʻana i nā mea hoʻohuihui ʻano paʻakikī.Loaʻa i ka CF12 nā pūʻulu hana e like me ka chloro a me ka fluoro substituents, hiki ke hoʻohana ʻia e hoʻolauna i nā hui makemake ʻē aʻe a i ʻole nā ​​​​hoʻololi hoʻololi.ʻO kēia ka mea e hiki ai i nā chemists ke hoʻopilikino i nā waiwai o ka pūhui a hoʻonui i kona mau hiʻohiʻona lāʻau lapaʻau no nā noi kikoʻī. Ua hōʻike ʻo CF12 i ka hiki ke hoʻomohala i nā moho lāʻau lapaʻau no nā wahi lapaʻau.Eia kekahi laʻana, hiki i ka hikiʻana o ka chloro a me ka fluoro substituents i CF12 ke hoʻonui i ka lipophilicity o ka pūhui, hiki ke hoʻonui i kona hiki ke komo i nā membrane biological a hoʻonui i ka laweʻana i ka lāʻau.Makemake nui ʻia kēia waiwai i ka hoʻolālā ʻana i nā lāʻau lapaʻau waha.Ua hōʻike ʻia ka hui pū ʻana o nā mea hoʻohui halogen e hōʻike i ka hana antimicrobial ākea ākea e kūʻē i nā ʻano like ʻole o ka bacteria a me nā haʻi.Ua wehe kēia i nā mea hiki ke noiʻi ʻia ka CF12 no ka hoʻomohala ʻana i nā lāʻau antibiotic hou a i ʻole nā ​​​​lāʻau antifungal.Ua hōʻike nā haʻawina e hōʻike ana ka CF12 i nā waiwai anti-inflammatory koʻikoʻi, hiki ke lilo i mea waiwai no ka mālama ʻana i nā maʻi i hōʻike ʻia e ka mumū, e like me nā maʻi autoimmune a i ʻole nā ​​​​maʻi inflammatory mau. noiʻi a hoʻomohala ʻia e hoʻomaopopo pono i kona hiki ke lilo i moho lāʻau.Pono nā haʻawina preclinical nui, me ka hoʻāʻo in vitro a me in vivo, e loiloi i ka pono o CF12, nā waiwai pharmacokinetic, a me ka ʻike palekana.Eia kekahi, pono ka hoʻonui ʻana i ka hoʻolālā kemika o CF12 a me ka ʻimi ʻana i kāna hana e kūʻē i nā pahuhopu maʻi kikoʻī e wehe i kona hiki ke hoʻōla piha. paʻa i ka ʻōlelo hoʻohiki no ka noiʻi lāʻau lapaʻau a me ka synthesis.ʻO kāna versatility ma ke ʻano he hale kūkulu hale e hiki ai i ka hana ʻana i nā pūhui organik paʻakikī, ʻoiai ʻo kāna mau hiʻohiʻona pharmacological e like me ka lipophilicity a me ka hana antimicrobial e lilo ia i moho kūpono no ka hoʻomohala ʻana i ka lāʻau lapaʻau ma nā wahi e like me nā antibiotics, antifungals, a me nā anti-inflammatory agents.Eia nō naʻe, pono ka noiʻi nui e loiloi piha i kona hiki ke hoʻoponopono a hoʻoholo i kona hiki ʻana ma ke ʻano he moho lāʻau.