2′-Deoxyuridine Cas:951-78-0
| Helu Helu | XD90583 |
| inoa mea kūʻai | 2'-Deoxyuridine |
| CAS | 951-78-0 |
| ʻĀpana Molekala | C9H12N2O5 |
| Kaumaha Molecular | 228.20 |
| Nā kikoʻī mālama | 2 a 8 °C |
| Kānāwai Kūʻai Kūlike | 29349990 |
Huahana Huahana
| Ka nana aku | ʻO ka pauka keʻokeʻo keʻokeʻo |
| Hoʻāʻo | 99% |
| Lae hehee | 164 - 168 Deg C |
| Nalo ma ka maloo | <1.0% |
| Koena ma ka Ignition | <0.1% |
He mea nui ka hoʻohana ʻana i ka nitrogen i nā pipi i mea e hoʻopaʻa ai i ka hana pipi hoʻomau.Ma muli o ka purines a me ka pyrimidines (PP) he hapa nui o ka nitrogen rumen, he mea nui ka hoʻomaopopo ʻana i ka absorption a me ka metabolism intermediary o PP.Hōʻike ka hana o kēia manawa i ka hoʻomohala ʻana a me ka hōʻoia ʻana o kahi ala koʻikoʻi a kikoʻī no ka hoʻoholo like ʻana o 20 purines (adenine, guanine, guanosine, inosine, 2'-deoxyguanosine, 2'-deoxyinosine, xanthine, hypoxanthine), pyrimidines (cytosine, thymine, uracil, cytidine, uridine, thymidine, 2'-deoxyuridine), a me kā lākou huahana degradation (uric acid, allantoin, β-alanine, β-ureidopropionic acid, β-aminoisobutyric acid) i loko o ke koko koko o nā bipi waiu.Ua hui pū ʻia ke ʻano hana kiʻekiʻe e pili ana i ka chromatography wai i hui pū ʻia me ka electrospray ionization tandem mass spectrometry (LC-MS/MS) me nā matrix-matched calibration standards a me nā pūhui kuhikuhi isotopically paʻa.Ua hoʻomaka mua ʻia ka loiloi quantitative e kahi kaʻina hana hoʻomaʻamaʻa hou e pili ana i ka ethanol precipitation, kānana, evaporation a me ka hoʻoponopono hou ʻana.Ua noiʻi ʻia nā ʻāpana no ka hoʻokaʻawale ʻana a me ka ʻike ʻana i ka wā o ka loiloi LC-MS/MS.Ua hōʻoia ʻia ʻo ka hoʻohana ʻana i kahi kumu hoʻohālike log-calibration ma mua o kahi hoʻohālike linear calibration i hopena i ka CV% haʻahaʻa a me ka nele o ka hoʻāʻo kūpono i hōʻike i kahi regression linear ʻoluʻolu.Hoʻopili ke ʻano i nā pae koʻikoʻi no kēlā me kēia metabolite e like me kēlā i nā laʻana maoli, e laʻa me guanine: 0.10-5.0 μmol/L, a me allantoin: 120-500 μmol/L.ʻO ka CV% no nā pae helu helu i koho ʻia ma lalo o 25%.Loaʻa i ke ʻano ka hana hou (CV% ≤25%) a me ka pololei waena (CV% ≤25%) a me nā hoʻihoʻi maikaʻi (91-107%).Ua hōʻike ʻia nā metabolites a pau i ke kūpaʻa lōʻihi a me ke kūpaʻa maikaʻi i loko o ka holo (CV%≤10%).Ua ʻike ʻia nā pae like ʻole o ka hopena matrix ma ka plasma, ka mimi a me ka waiū.ʻO ka hoʻoholo ʻana i nā hopena matrix pili i hōʻike ʻia ua kūpono ke ʻano no ka aneane āpau i nānā ʻia i nā metabolites PP i loko o ka plasma i huki ʻia mai kahi aʻa a me ka portal hepatic, hepatic a me nā veins gastrosplenic a, me kekahi mau ʻokoʻa, no nā ʻano ʻē aʻe e like me ka moa, puaʻa, mink, kanaka a iole.
